Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody

Immune checkpoint inhibitors (ICIs) are complicated by immune-related adverse events (irAEs), such as myositis, myocarditis, and myasthenia gravis (MG). Anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody are anti-striated antibodies that are frequently detected in MG patient...

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Autores principales: Ono, Ryohei, Iwai, Yuta, Yamazaki, Tatsuro, Takahashi, Hidehisa, Hori, Yasuhiko, Fukushima, Kenichi, Saotome, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593150/
https://www.ncbi.nlm.nih.gov/pubmed/35314545
http://dx.doi.org/10.2169/internalmedicine.8772-21
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author Ono, Ryohei
Iwai, Yuta
Yamazaki, Tatsuro
Takahashi, Hidehisa
Hori, Yasuhiko
Fukushima, Kenichi
Saotome, Takashi
author_facet Ono, Ryohei
Iwai, Yuta
Yamazaki, Tatsuro
Takahashi, Hidehisa
Hori, Yasuhiko
Fukushima, Kenichi
Saotome, Takashi
author_sort Ono, Ryohei
collection PubMed
description Immune checkpoint inhibitors (ICIs) are complicated by immune-related adverse events (irAEs), such as myositis, myocarditis, and myasthenia gravis (MG). Anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody are anti-striated antibodies that are frequently detected in MG patients with myositis and/or myocarditis. However, the clinical relationship between positive anti-striated antibodies and irAEs of ICIs remains unknown. We herein report a case of nivolumab-induced myositis and myocarditis with positive anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody in a patient with non-small-cell lung cancer. We also review reported cases of positive anti-striated antibodies related to irAEs of ICIs.
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spelling pubmed-95931502022-11-07 Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody Ono, Ryohei Iwai, Yuta Yamazaki, Tatsuro Takahashi, Hidehisa Hori, Yasuhiko Fukushima, Kenichi Saotome, Takashi Intern Med Case Report Immune checkpoint inhibitors (ICIs) are complicated by immune-related adverse events (irAEs), such as myositis, myocarditis, and myasthenia gravis (MG). Anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody are anti-striated antibodies that are frequently detected in MG patients with myositis and/or myocarditis. However, the clinical relationship between positive anti-striated antibodies and irAEs of ICIs remains unknown. We herein report a case of nivolumab-induced myositis and myocarditis with positive anti-titin antibody and anti-voltage-gated potassium channel Kv1.4 antibody in a patient with non-small-cell lung cancer. We also review reported cases of positive anti-striated antibodies related to irAEs of ICIs. The Japanese Society of Internal Medicine 2022-03-19 2022-10-01 /pmc/articles/PMC9593150/ /pubmed/35314545 http://dx.doi.org/10.2169/internalmedicine.8772-21 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ono, Ryohei
Iwai, Yuta
Yamazaki, Tatsuro
Takahashi, Hidehisa
Hori, Yasuhiko
Fukushima, Kenichi
Saotome, Takashi
Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody
title Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody
title_full Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody
title_fullStr Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody
title_full_unstemmed Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody
title_short Nivolumab-induced Myositis and Myocarditis with Positive Anti-titin Antibody and Anti-voltage-gated Potassium Channel Kv1.4 Antibody
title_sort nivolumab-induced myositis and myocarditis with positive anti-titin antibody and anti-voltage-gated potassium channel kv1.4 antibody
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593150/
https://www.ncbi.nlm.nih.gov/pubmed/35314545
http://dx.doi.org/10.2169/internalmedicine.8772-21
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