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Histone Deacetylase Inhibition Restores Behavioral and Synaptic Function in a Mouse Model of 16p11.2 Deletion

BACKGROUND: Microdeletion of the human 16p11.2 gene locus confers risk for autism spectrum disorders and intellectual disability. How 16p11.2 deletion is linked to these neurodevelopmental disorders and whether there are treatment avenues for the manifested phenotypes remain to be elucidated. Emergi...

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Detalles Bibliográficos
Autores principales: Wang, Wei, Tan, Tao, Cao, Qing, Zhang, Freddy, Rein, Benjamin, Duan, Wei-Ming, Yan, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593221/
https://www.ncbi.nlm.nih.gov/pubmed/35907244
http://dx.doi.org/10.1093/ijnp/pyac048