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Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status

BACKGROUND: Whole-body magnetic resonance imaging (MRI) permits non-invasive, non-ionizing phenotyping of the human body and ideally complements the epidemiological assessment of the NAKO participants. As such, it allows for the detection of morphologic or functional predisposition, early disease st...

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Autor principal: Bamberg, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593852/
http://dx.doi.org/10.1093/eurpub/ckac129.029
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author Bamberg, F
author_facet Bamberg, F
author_sort Bamberg, F
collection PubMed
description BACKGROUND: Whole-body magnetic resonance imaging (MRI) permits non-invasive, non-ionizing phenotyping of the human body and ideally complements the epidemiological assessment of the NAKO participants. As such, it allows for the detection of morphologic or functional predisposition, early disease stages prior to overt clinical events as well as evident pathological changes. The assessment of progression and regression of imaging phenotypes over time will provide the basis to identify and understand the relevance of imaging-based risk factor profiles for disease development. METHODS: Integrated in the general NAKO study program and managed by a central Imaging Core, study participants underwent whole-body imaging at five dedicated MR imaging sites. Imaging was performed on five identical 3 Tesla scanners (Magnetom Skyra, Siemens Healthineers, Erlangen, Germany) applying a one hour protocol, including sequences for the brain, the cardiovascular and musculoskeletal system as well as for the thorax and abdomen. Comprehensive measures to assure high image quality and management of incidental findings were established. RESULTS: As part of the baseline examination program, a total of 30,861 participants successfully underwent the MR imaging program. All measures of quality assurance and incidental findings management were successfully employed throughout the study period and obtained image quality and completeness of all MR sequences was excellent (>94.2% completeness). While MR imaging as part of the first re-examination is ongoing, baseline MRI data is currently accessible for scientific analyses. CONCLUSIONS: The MRI-Study of the NAKO will provide a comprehensive imaging phenotypic biobank covering different organ systems with highest morphological and functional detail. MRI data analysis will gain novel insights into the natural history of disease development, the role of subclinical disease burden, and revolutionize our understanding of imaging biomarkers of risk.
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spelling pubmed-95938522022-11-22 Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status Bamberg, F Eur J Public Health Parallel Programme BACKGROUND: Whole-body magnetic resonance imaging (MRI) permits non-invasive, non-ionizing phenotyping of the human body and ideally complements the epidemiological assessment of the NAKO participants. As such, it allows for the detection of morphologic or functional predisposition, early disease stages prior to overt clinical events as well as evident pathological changes. The assessment of progression and regression of imaging phenotypes over time will provide the basis to identify and understand the relevance of imaging-based risk factor profiles for disease development. METHODS: Integrated in the general NAKO study program and managed by a central Imaging Core, study participants underwent whole-body imaging at five dedicated MR imaging sites. Imaging was performed on five identical 3 Tesla scanners (Magnetom Skyra, Siemens Healthineers, Erlangen, Germany) applying a one hour protocol, including sequences for the brain, the cardiovascular and musculoskeletal system as well as for the thorax and abdomen. Comprehensive measures to assure high image quality and management of incidental findings were established. RESULTS: As part of the baseline examination program, a total of 30,861 participants successfully underwent the MR imaging program. All measures of quality assurance and incidental findings management were successfully employed throughout the study period and obtained image quality and completeness of all MR sequences was excellent (>94.2% completeness). While MR imaging as part of the first re-examination is ongoing, baseline MRI data is currently accessible for scientific analyses. CONCLUSIONS: The MRI-Study of the NAKO will provide a comprehensive imaging phenotypic biobank covering different organ systems with highest morphological and functional detail. MRI data analysis will gain novel insights into the natural history of disease development, the role of subclinical disease burden, and revolutionize our understanding of imaging biomarkers of risk. Oxford University Press 2022-10-25 /pmc/articles/PMC9593852/ http://dx.doi.org/10.1093/eurpub/ckac129.029 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the European Public Health Association. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Parallel Programme
Bamberg, F
Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status
title Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status
title_full Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status
title_fullStr Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status
title_full_unstemmed Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status
title_short Whole-body Magnetic Resonance Imaging in the German National Cohort (NAKO): Design & Current Status
title_sort whole-body magnetic resonance imaging in the german national cohort (nako): design & current status
topic Parallel Programme
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593852/
http://dx.doi.org/10.1093/eurpub/ckac129.029
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