Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study

This study aimed to estimate the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) against invasive pneumococcal disease (IPD) among individuals ≥ 65 years of age. We used Danish nationwide databases to obtain information on PPV23 vaccination, covariates, and IPD and linked...

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Autores principales: Nielsen, Katrine Finderup, Nielsen, Lise Birk, Lomholt, Frederikke Kristensen, Nørgaard, Sarah Kristine, Slotved, Hans-Christian, Dalby, Tine, Fuursted, Kurt, Jørgensen, Charlotte Sværke, Valentiner-Branth, Palle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593971/
https://www.ncbi.nlm.nih.gov/pubmed/36282341
http://dx.doi.org/10.1007/s10096-022-04513-5
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author Nielsen, Katrine Finderup
Nielsen, Lise Birk
Lomholt, Frederikke Kristensen
Nørgaard, Sarah Kristine
Slotved, Hans-Christian
Dalby, Tine
Fuursted, Kurt
Jørgensen, Charlotte Sværke
Valentiner-Branth, Palle
author_facet Nielsen, Katrine Finderup
Nielsen, Lise Birk
Lomholt, Frederikke Kristensen
Nørgaard, Sarah Kristine
Slotved, Hans-Christian
Dalby, Tine
Fuursted, Kurt
Jørgensen, Charlotte Sværke
Valentiner-Branth, Palle
author_sort Nielsen, Katrine Finderup
collection PubMed
description This study aimed to estimate the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) against invasive pneumococcal disease (IPD) among individuals ≥ 65 years of age. We used Danish nationwide databases to obtain information on PPV23 vaccination, covariates, and IPD and linked data on an individual level using a unique personal identifier. A total of 948,263 individuals were included and followed between June 15, 2020, and September 18, 2021 (58.6% were vaccinated during follow-up). The adjusted vaccine effectiveness was 42% (95% confidence interval (CI): 9–63%) for all-serotype IPD and 58% (95% CI: 21–78%) for PPV23-serotype IPD, using no vaccination as the reference. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-022-04513-5.
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spelling pubmed-95939712022-10-25 Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study Nielsen, Katrine Finderup Nielsen, Lise Birk Lomholt, Frederikke Kristensen Nørgaard, Sarah Kristine Slotved, Hans-Christian Dalby, Tine Fuursted, Kurt Jørgensen, Charlotte Sværke Valentiner-Branth, Palle Eur J Clin Microbiol Infect Dis Brief Report This study aimed to estimate the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPV23) against invasive pneumococcal disease (IPD) among individuals ≥ 65 years of age. We used Danish nationwide databases to obtain information on PPV23 vaccination, covariates, and IPD and linked data on an individual level using a unique personal identifier. A total of 948,263 individuals were included and followed between June 15, 2020, and September 18, 2021 (58.6% were vaccinated during follow-up). The adjusted vaccine effectiveness was 42% (95% confidence interval (CI): 9–63%) for all-serotype IPD and 58% (95% CI: 21–78%) for PPV23-serotype IPD, using no vaccination as the reference. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-022-04513-5. Springer Berlin Heidelberg 2022-10-25 2022 /pmc/articles/PMC9593971/ /pubmed/36282341 http://dx.doi.org/10.1007/s10096-022-04513-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Report
Nielsen, Katrine Finderup
Nielsen, Lise Birk
Lomholt, Frederikke Kristensen
Nørgaard, Sarah Kristine
Slotved, Hans-Christian
Dalby, Tine
Fuursted, Kurt
Jørgensen, Charlotte Sværke
Valentiner-Branth, Palle
Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study
title Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study
title_full Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study
title_fullStr Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study
title_full_unstemmed Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study
title_short Effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a Danish cohort study
title_sort effectiveness of the 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease among 948,263 individuals ≥ 65 years of age: a danish cohort study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593971/
https://www.ncbi.nlm.nih.gov/pubmed/36282341
http://dx.doi.org/10.1007/s10096-022-04513-5
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