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Direct, indirect, post-infection damages induced by coronavirus in the human body: an overview

BACKGROUND: Severe acute respiratory syndrome Coronavirus-2 invades the cells via ACE2 receptor and damages multiple organs of the human body. Understanding the pathological manifestation is mandatory to endure the rising post-infection sequel reported in patients with or without comorbidities. MATE...

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Detalles Bibliográficos
Autores principales: Priya, Sivan Padma, Sunil, P. M., Varma, Sudhir, Brigi, Carel, Isnadi, Mohammad Faruq Abd Rachman, Jayalal, J. A., Shadamarshan, R. Arunkumar, Kumar, S. Suresh, Kumari, Neela Vasantha, Kumar, Rishi P. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer India 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593972/
https://www.ncbi.nlm.nih.gov/pubmed/36311173
http://dx.doi.org/10.1007/s13337-022-00793-9
Descripción
Sumario:BACKGROUND: Severe acute respiratory syndrome Coronavirus-2 invades the cells via ACE2 receptor and damages multiple organs of the human body. Understanding the pathological manifestation is mandatory to endure the rising post-infection sequel reported in patients with or without comorbidities. MATERIALS AND METHODS: Our descriptive review emphasises the direct, indirect and post-infection damages due to COVID-19. We have performed an electronic database search according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines with selective inclusion and exclusion criteria. RESULTS: The included studies substantiated the extensive damages in the multiple organs due to direct and indirect consequences of COVID-19. After an apparent recovery, the prolonged presentation of the symptoms manifests as post-COVID that can be related with persisting viral antigens and dysregulated immune response. CONCLUSION: A few of the symptoms of respiratory, cardiovascular, and neuropsychiatric systems that persist or reappear as post-COVID manifestations. Vaccination and preventive programs will effectively reduce the prevalence but, the post-COVID, a multisystem manifestation, will be a significant tribulation to the medical profession. However, the issue can be managed by implementing public health programs, rehabilitation services, and telemedicine virtual supports to raise awareness and reduce panic.