Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

[Image: see text] Recently determined structures of class C G protein-coupled receptors (GPCRs) revealed the location of allosteric binding sites and opened new opportunities for the discovery of novel modulators. In this work, molecular docking screens for allosteric modulators targeting the metabo...

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Detalles Bibliográficos
Autores principales: Kampen, Stefanie, Rodríguez, David, Jørgensen, Morten, Kruszyk-Kujawa, Monika, Huang, Xinyan, Collins, Michael, Boyle, Noel, Maurel, Damien, Rudling, Axel, Lebon, Guillaume, Carlsson, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594040/
https://www.ncbi.nlm.nih.gov/pubmed/36149353
http://dx.doi.org/10.1021/acschembio.2c00234

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