NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome

Wolfram syndrome (WS) is a rare neurodegenerative disease resulting in deafness, optic atrophy, diabetes, and neurological disorders. Currently, no treatment is available for patients. The mutated gene, WFS1, encodes an endoplasmic reticulum (ER) protein, Wolframin. We previously reported that Wolfr...

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Detalles Bibliográficos
Autores principales: Crouzier, Lucie, Richard, Elodie M., Diez, Camille, Denus, Morgane, Peyrel, Amandine, Alzaeem, Hala, Cubedo, Nicolas, Delaunay, Thomas, Maurice, Tangui, Delprat, Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594121/
https://www.ncbi.nlm.nih.gov/pubmed/36320410
http://dx.doi.org/10.1016/j.omtm.2022.10.003

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