Cargando…

A calculated risk: Evaluating HIV resistance to the broadly neutralising antibodies10-1074 and 3BNC117

Broadly neutralising antibodies (bNAbs) are a promising new therapy for the treatment of HIV infection. However, the effective use of bNAbs is impacted by the presence of preexisting virological resistance and the potential to develop new resistance during treatment. With several bNAb clinical trial...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zacharopoulou, Panagiota, Ansari, M. Azim, Frater, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	THERAPEUTIC VACCINES: Edited by Beatriz Mothe
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594129/ https://www.ncbi.nlm.nih.gov/pubmed/36178770 http://dx.doi.org/10.1097/COH.0000000000000764

Ejemplares similares

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study
por: Cohen, Yehuda Z., et al.
Publicado: (2019)

Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies
por: Patel, Ashaben, et al.
Publicado: (2018)

Human papillomavirus vaccination induces neutralising antibodies in oral mucosal fluids
por: Handisurya, A, et al.
Publicado: (2016)

Relationship between latent and rebound viruses in a clinical trial of anti–HIV-1 antibody 3BNC117
por: Cohen, Yehuda Z., et al.
Publicado: (2018)

Mucosal application of the broadly neutralizing antibody 10-1074 protects macaques from cell-associated SHIV vaginal exposure
por: Suphaphiphat, Karunasinee, et al.
Publicado: (2023)

Decreased Expression of BNC1 and BNC2 Is Associated with Genetic or Epigenetic Regulation in Hepatocellular Carcinoma
por: Wu, Yali, et al.
Publicado: (2016)

Comparison of Antibody Responses Induced by RV144, VAX003, and VAX004 Vaccination Regimens
por: Karnasuta, Chitraporn, et al.
Publicado: (2017)

Antibody-Based Correlates of Protection against Cholera: Analysis of a Challenge Study of a Cholera-Naive Population
por: Haney, Douglas J., et al.
Publicado: (2017)

A radiolabeled mAb 3BNC117 with copper-64: First round in favor for studying clearance of HIV reservoirs
por: León, Segundo R.
Publicado: (2021)

Effect of Vaccine-Elicited Antibodies on Colonization of Neisseria meningitidis Serogroup B and C Strains in a Human Bronchial Epithelial Cell Culture Model
por: Vianzon, Vianca, et al.
Publicado: (2017)

Optimization of the EC26-2A4 Epitope in the gp41 Membrane Proximal External Region Targeted by Neutralizing Antibodies from an Elite Controller
por: Ringel, Oliver, et al.
Publicado: (2018)

Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening
por: Yang, Xuehua, et al.
Publicado: (2023)

Neutralizing Antibody Responses to Antigenically Drifted Influenza A(H3N2) Viruses among Children and Adolescents following 2014-2015 Inactivated and Live Attenuated Influenza Vaccination
por: Levine, Min Z., et al.
Publicado: (2016)

Antibody Persistence in Young Children 5 Years after Vaccination with a Combined Haemophilus influenzae Type b-Neisseria meningitidis Serogroup C Conjugate Vaccine Coadministered with Diphtheria-Tetanus-Acellular Pertussis-Based and Pneumococcal Conjugate Vaccines
por: Tejedor, Juan Carlos, et al.
Publicado: (2016)

Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
por: Haynes, Barton F., et al.
Publicado: (2023)

IgG Antibody Responses to Recombinant gp120 Proteins, gp70V1/V2 Scaffolds, and a CyclicV2 Peptide in Thai Phase I/II Vaccine Trials Using Different Vaccine Regimens
por: Karasavvas, Nicos, et al.
Publicado: (2015)

Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies
por: Cheeseman, Hannah M., et al.
Publicado: (2016)

Broadly neutralizing antibody epitopes on HIV-1 particles are exposed after virus interaction with host cells
por: Rao, Priyanka Gadam, et al.
Publicado: (2023)

La libreta morada : gesta de una mujer común y sus divagaciones /
por: Graf, Beatriz
Publicado: (2000)

Implementation of a real-time, data-driven online Epidemic Calculator for tracking the spread of COVID-19 in Singapore and other countries
por: Yap, Fook Fah, et al.
Publicado: (2021)

Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle Vaccines
por: Sun, Cong, et al.
Publicado: (2022)

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer
por: Zhan, Wuqiang, et al.
Publicado: (2022)

Airway Delivery of Anti-influenza Monoclonal Antibodies Results in Enhanced Antiviral Activities and Enables Broad-Coverage Combination Therapies
por: Vigil, Adam, et al.
Publicado: (2020)

Broadly Inhibiting Antineuraminidase Monoclonal Antibodies Induced by Trivalent Influenza Vaccine and H7N9 Infection in Humans
por: Rijal, Pramila, et al.
Publicado: (2020)

Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection
por: Huang, Jiachen, et al.
Publicado: (2021)

Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies
por: Kim, Soohyun, et al.
Publicado: (2022)

Characteristics of patients receiving allergy vaccination: to which extent do socio-economic factors play a role?
por: Petersen, Karin Dam, et al.
Publicado: (2011)

Implications of Differential Age Distribution of Disease-Associated Meningococcal Lineages for Vaccine Development
por: Brehony, Carina, et al.
Publicado: (2014)

Process of Assay Selection and Optimization for the Study of Case and Control Samples from a Phase IIb Efficacy Trial of a Candidate Tuberculosis Vaccine, MVA85A
por: Harris, Stephanie A., et al.
Publicado: (2014)

Comparative Efficacy of Feline Leukemia Virus (FeLV) Inactivated Whole-Virus Vaccine and Canarypox Virus-Vectored Vaccine during Virulent FeLV Challenge and Immunosuppression
por: Patel, M., et al.
Publicado: (2015)

Characterization of T-Cell Responses to Conserved Regions of the HIV-1 Proteome in BALB/c Mice
por: Ondondo, Beatrice, et al.
Publicado: (2014)

Toll-Like Receptor Activation by Generalized Modules for Membrane Antigens from Lipid A Mutants of Salmonella enterica Serovars Typhimurium and Enteritidis
por: Rossi, Omar, et al.
Publicado: (2016)

Correlates of Protection against Influenza in the Elderly: Results from an Influenza Vaccine Efficacy Trial
por: Dunning, Andrew J., et al.
Publicado: (2016)

Evaluation of the Immunogenicity of Mycobacterium bovis BCG Delivered by Aerosol to the Lungs of Macaques
por: White, A. D., et al.
Publicado: (2015)

The Carbomer-Lecithin Adjuvant Adjuplex Has Potent Immunoactivating Properties and Elicits Protective Adaptive Immunity against Influenza Virus Challenge in Mice
por: Wegmann, Frank, et al.
Publicado: (2015)

Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin
por: Fiaschi, Luigi, et al.
Publicado: (2016)

Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap
por: Gray, Glenda E., et al.
Publicado: (2016)

Novel Respiratory Syncytial Virus-Like Particle Vaccine Composed of the Postfusion and Prefusion Conformations of the F Glycoprotein
por: Cimica, Velasco, et al.
Publicado: (2016)

Characterization of Influenza Vaccine Hemagglutinin Complexes by Cryo-Electron Microscopy and Image Analyses Reveals Structural Polymorphisms
por: McCraw, Dustin M., et al.
Publicado: (2016)

Attenuation of Replication-Competent Adenovirus Serotype 26 Vaccines by Vectorization
por: Maxfield, Lori F., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_dlkrl1c7oudqpvcto0uj7toefa