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Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation

Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be f...

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Detalles Bibliográficos
Autores principales: Dietrich, Elisa, Jomard, Anne, Osto, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594152/
https://www.ncbi.nlm.nih.gov/pubmed/36304545
http://dx.doi.org/10.3389/fcvm.2022.989428
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author Dietrich, Elisa
Jomard, Anne
Osto, Elena
author_facet Dietrich, Elisa
Jomard, Anne
Osto, Elena
author_sort Dietrich, Elisa
collection PubMed
description Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be further elucidated. Endothelial cell homeostasis is fundamental to prevent atherosclerosis as the appearance of endothelial cell dysfunction is considered the first pro-atherosclerotic vascular modification. Physiologically, high density lipoproteins (HDLs) exert protective actions for vessels and in particular for ECs. Indeed, HDLs promote endothelial-dependent vasorelaxation, contribute to the regulation of vascular lipid metabolism, and have immune-modulatory, anti-inflammatory and anti-oxidative properties. Sex- and gender-dependent differences are increasingly recognized as important, although not fully elucidated, factors in cardiovascular health and disease patho-physiology. In this review, we highlight the importance of sex hormones and sex-specific gene expression in the regulation of HDL and EC cross-talk and their contribution to cardiovascular disease.
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spelling pubmed-95941522022-10-26 Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation Dietrich, Elisa Jomard, Anne Osto, Elena Front Cardiovasc Med Cardiovascular Medicine Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be further elucidated. Endothelial cell homeostasis is fundamental to prevent atherosclerosis as the appearance of endothelial cell dysfunction is considered the first pro-atherosclerotic vascular modification. Physiologically, high density lipoproteins (HDLs) exert protective actions for vessels and in particular for ECs. Indeed, HDLs promote endothelial-dependent vasorelaxation, contribute to the regulation of vascular lipid metabolism, and have immune-modulatory, anti-inflammatory and anti-oxidative properties. Sex- and gender-dependent differences are increasingly recognized as important, although not fully elucidated, factors in cardiovascular health and disease patho-physiology. In this review, we highlight the importance of sex hormones and sex-specific gene expression in the regulation of HDL and EC cross-talk and their contribution to cardiovascular disease. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9594152/ /pubmed/36304545 http://dx.doi.org/10.3389/fcvm.2022.989428 Text en Copyright © 2022 Dietrich, Jomard and Osto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Dietrich, Elisa
Jomard, Anne
Osto, Elena
Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
title Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
title_full Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
title_fullStr Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
title_full_unstemmed Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
title_short Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
title_sort crosstalk between high-density lipoproteins and endothelial cells in health and disease: insights into sex-dependent modulation
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594152/
https://www.ncbi.nlm.nih.gov/pubmed/36304545
http://dx.doi.org/10.3389/fcvm.2022.989428
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