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Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation
Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be f...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594152/ https://www.ncbi.nlm.nih.gov/pubmed/36304545 http://dx.doi.org/10.3389/fcvm.2022.989428 |
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author | Dietrich, Elisa Jomard, Anne Osto, Elena |
author_facet | Dietrich, Elisa Jomard, Anne Osto, Elena |
author_sort | Dietrich, Elisa |
collection | PubMed |
description | Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be further elucidated. Endothelial cell homeostasis is fundamental to prevent atherosclerosis as the appearance of endothelial cell dysfunction is considered the first pro-atherosclerotic vascular modification. Physiologically, high density lipoproteins (HDLs) exert protective actions for vessels and in particular for ECs. Indeed, HDLs promote endothelial-dependent vasorelaxation, contribute to the regulation of vascular lipid metabolism, and have immune-modulatory, anti-inflammatory and anti-oxidative properties. Sex- and gender-dependent differences are increasingly recognized as important, although not fully elucidated, factors in cardiovascular health and disease patho-physiology. In this review, we highlight the importance of sex hormones and sex-specific gene expression in the regulation of HDL and EC cross-talk and their contribution to cardiovascular disease. |
format | Online Article Text |
id | pubmed-9594152 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95941522022-10-26 Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation Dietrich, Elisa Jomard, Anne Osto, Elena Front Cardiovasc Med Cardiovascular Medicine Atherosclerotic cardiovascular disease is the leading cause of death worldwide. Intense research in vascular biology has advanced our knowledge of molecular mechanisms of its onset and progression until complications; however, several aspects of the patho-physiology of atherosclerosis remain to be further elucidated. Endothelial cell homeostasis is fundamental to prevent atherosclerosis as the appearance of endothelial cell dysfunction is considered the first pro-atherosclerotic vascular modification. Physiologically, high density lipoproteins (HDLs) exert protective actions for vessels and in particular for ECs. Indeed, HDLs promote endothelial-dependent vasorelaxation, contribute to the regulation of vascular lipid metabolism, and have immune-modulatory, anti-inflammatory and anti-oxidative properties. Sex- and gender-dependent differences are increasingly recognized as important, although not fully elucidated, factors in cardiovascular health and disease patho-physiology. In this review, we highlight the importance of sex hormones and sex-specific gene expression in the regulation of HDL and EC cross-talk and their contribution to cardiovascular disease. Frontiers Media S.A. 2022-10-06 /pmc/articles/PMC9594152/ /pubmed/36304545 http://dx.doi.org/10.3389/fcvm.2022.989428 Text en Copyright © 2022 Dietrich, Jomard and Osto. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Dietrich, Elisa Jomard, Anne Osto, Elena Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation |
title | Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation |
title_full | Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation |
title_fullStr | Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation |
title_full_unstemmed | Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation |
title_short | Crosstalk between high-density lipoproteins and endothelial cells in health and disease: Insights into sex-dependent modulation |
title_sort | crosstalk between high-density lipoproteins and endothelial cells in health and disease: insights into sex-dependent modulation |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594152/ https://www.ncbi.nlm.nih.gov/pubmed/36304545 http://dx.doi.org/10.3389/fcvm.2022.989428 |
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