Genetically Encoded Whole Cell Biosensor for Drug Discovery of HIF-1 Interaction Inhibitors

[Image: see text] The heterodimeric transcription factor, hypoxia inducible factor-1 (HIF-1), is an important anticancer target as it supports the adaptation and response of tumors to hypoxia. Here, we optimized the repressed transactivator yeast two-hybrid system to further develop it as part of a...

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Detalles Bibliográficos
Autores principales: Scott, Louis H., Wigglesworth, Mark J., Siewers, Verena, Davis, Andrew M., David, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594322/
https://www.ncbi.nlm.nih.gov/pubmed/36223492
http://dx.doi.org/10.1021/acssynbio.2c00274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594322/
https://www.ncbi.nlm.nih.gov/pubmed/36223492
http://dx.doi.org/10.1021/acssynbio.2c00274

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