Cargando…
Breast cancer trends in women in Cyprus: a population-based study between 2004-2017
BACKGROUND: In Cyprus, breast cancer (BC) is the first in incidence and second in mortality cancer in women. A national screening programme (NSP), targeting women 50-69 years, was introduced in 2007. The aim of this study is to provide a better understanding of cancer trends. METHODS: Data from the...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594357/ http://dx.doi.org/10.1093/eurpub/ckac131.141 |
_version_ | 1784815395376463872 |
---|---|
author | Quattrocchi, A Demetriou, CA Cory, OA Saad, B Constantinou, C Marcou, Y Demetriou, A Scoutellas, V Kolokotroni, O |
author_facet | Quattrocchi, A Demetriou, CA Cory, OA Saad, B Constantinou, C Marcou, Y Demetriou, A Scoutellas, V Kolokotroni, O |
author_sort | Quattrocchi, A |
collection | PubMed |
description | BACKGROUND: In Cyprus, breast cancer (BC) is the first in incidence and second in mortality cancer in women. A national screening programme (NSP), targeting women 50-69 years, was introduced in 2007. The aim of this study is to provide a better understanding of cancer trends. METHODS: Data from the national population-based Cyprus Cancer Registry on adult women diagnosed with BC between 2004-2017 with follow-up until 2019 were analysed as follows: Joinpoint regression for age-adjusted (overall and by tumor stage at diagnosis - TSD) and age-specific rates (<50, 50-59, 60-69, 70-79, ≥ 80) incidence and mortality rates; 5-year age-adjusted Net Survival (NS) rates, overall and by TSD. TSD was categorised as localised, regional, and distant. RESULTS: Age-adjusted incidence rate increased from 135.3 (2004) to 153.2 (2017) per 100,000, with an annual percentage change (APC) of 1.1% (95%CI: 0.4-1.9). The greatest increase was in the age groups ≥70 years. A positive time trend was found for localized cancers between 2006-2017, while for all other stages nonsignificant trends were detected. Age-adjusted mortality rate increased from 37.0 (2004) to 50.0 (2019) per 100,000 (APC: 2.7%; 95%CI: 1.9-9.4). Significant increases in mortality rates were detected in the age groups ≥70 years. By TSD, increased rates were found at localised and regional stages, however smaller increases were detected since 2007. NS rates for the most recent period (2014-2017) was 93% for localized, 81% for regional, and 32% for distant and did not significantly improve compared to the previous years. CONCLUSIONS: Trends in BC incidence continues to increase, especially in the older age groups and for early-stage cancers. As expected, since the introduction of the NSP, the incidence of localised cancers increased whilst the incidence of advanced stage cancer decreased, albeit non-significantly. Survival trends did not change but mortality rates for localised and regional cancers increased at a slower pace. KEY MESSAGES: • The introduction of the national screening programme may have played an important role in the increasing BC incidence trends. • Despite survival rates not improving since the introduction of the national screening programme, mortality rates for early-stage cancers show a less steep increase. |
format | Online Article Text |
id | pubmed-9594357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-95943572022-11-22 Breast cancer trends in women in Cyprus: a population-based study between 2004-2017 Quattrocchi, A Demetriou, CA Cory, OA Saad, B Constantinou, C Marcou, Y Demetriou, A Scoutellas, V Kolokotroni, O Eur J Public Health Poster Displays BACKGROUND: In Cyprus, breast cancer (BC) is the first in incidence and second in mortality cancer in women. A national screening programme (NSP), targeting women 50-69 years, was introduced in 2007. The aim of this study is to provide a better understanding of cancer trends. METHODS: Data from the national population-based Cyprus Cancer Registry on adult women diagnosed with BC between 2004-2017 with follow-up until 2019 were analysed as follows: Joinpoint regression for age-adjusted (overall and by tumor stage at diagnosis - TSD) and age-specific rates (<50, 50-59, 60-69, 70-79, ≥ 80) incidence and mortality rates; 5-year age-adjusted Net Survival (NS) rates, overall and by TSD. TSD was categorised as localised, regional, and distant. RESULTS: Age-adjusted incidence rate increased from 135.3 (2004) to 153.2 (2017) per 100,000, with an annual percentage change (APC) of 1.1% (95%CI: 0.4-1.9). The greatest increase was in the age groups ≥70 years. A positive time trend was found for localized cancers between 2006-2017, while for all other stages nonsignificant trends were detected. Age-adjusted mortality rate increased from 37.0 (2004) to 50.0 (2019) per 100,000 (APC: 2.7%; 95%CI: 1.9-9.4). Significant increases in mortality rates were detected in the age groups ≥70 years. By TSD, increased rates were found at localised and regional stages, however smaller increases were detected since 2007. NS rates for the most recent period (2014-2017) was 93% for localized, 81% for regional, and 32% for distant and did not significantly improve compared to the previous years. CONCLUSIONS: Trends in BC incidence continues to increase, especially in the older age groups and for early-stage cancers. As expected, since the introduction of the NSP, the incidence of localised cancers increased whilst the incidence of advanced stage cancer decreased, albeit non-significantly. Survival trends did not change but mortality rates for localised and regional cancers increased at a slower pace. KEY MESSAGES: • The introduction of the national screening programme may have played an important role in the increasing BC incidence trends. • Despite survival rates not improving since the introduction of the national screening programme, mortality rates for early-stage cancers show a less steep increase. Oxford University Press 2022-10-25 /pmc/articles/PMC9594357/ http://dx.doi.org/10.1093/eurpub/ckac131.141 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the European Public Health Association. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Poster Displays Quattrocchi, A Demetriou, CA Cory, OA Saad, B Constantinou, C Marcou, Y Demetriou, A Scoutellas, V Kolokotroni, O Breast cancer trends in women in Cyprus: a population-based study between 2004-2017 |
title | Breast cancer trends in women in Cyprus: a population-based study between 2004-2017 |
title_full | Breast cancer trends in women in Cyprus: a population-based study between 2004-2017 |
title_fullStr | Breast cancer trends in women in Cyprus: a population-based study between 2004-2017 |
title_full_unstemmed | Breast cancer trends in women in Cyprus: a population-based study between 2004-2017 |
title_short | Breast cancer trends in women in Cyprus: a population-based study between 2004-2017 |
title_sort | breast cancer trends in women in cyprus: a population-based study between 2004-2017 |
topic | Poster Displays |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594357/ http://dx.doi.org/10.1093/eurpub/ckac131.141 |
work_keys_str_mv | AT quattrocchia breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT demetriouca breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT coryoa breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT saadb breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT constantinouc breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT marcouy breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT demetrioua breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT scoutellasv breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 AT kolokotronio breastcancertrendsinwomenincyprusapopulationbasedstudybetween20042017 |