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Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose

We describe a 60-year-old female patient who suffered an apparently intentional overdose of lacosamide and who developed status epilepticus secondary to its toxicity, complicated by refractory ventricular arrhythmia necessitating advanced cardiac life support and percutaneous stellate ganglion block...

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Detalles Bibliográficos
Autores principales: Marcellino, Chris, Ransom, Chase C, Wijdicks, Eelco F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594684/
https://www.ncbi.nlm.nih.gov/pubmed/36312640
http://dx.doi.org/10.7759/cureus.29547
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author Marcellino, Chris
Ransom, Chase C
Wijdicks, Eelco F
author_facet Marcellino, Chris
Ransom, Chase C
Wijdicks, Eelco F
author_sort Marcellino, Chris
collection PubMed
description We describe a 60-year-old female patient who suffered an apparently intentional overdose of lacosamide and who developed status epilepticus secondary to its toxicity, complicated by refractory ventricular arrhythmia necessitating advanced cardiac life support and percutaneous stellate ganglion blockade. Extracorporeal membrane oxygenation was considered, and arterial and venous small-bore sheaths were placed in order to allow for extracorporeal cardiopulmonary resuscitation if cardiac arrest recurred, but they were not ultimately used. She suffered an embolic left middle cerebral artery stroke but otherwise recovered from the episode. This eventful clinical course highlights the dangers of lacosamide in high doses.
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spelling pubmed-95946842022-10-28 Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose Marcellino, Chris Ransom, Chase C Wijdicks, Eelco F Cureus Emergency Medicine We describe a 60-year-old female patient who suffered an apparently intentional overdose of lacosamide and who developed status epilepticus secondary to its toxicity, complicated by refractory ventricular arrhythmia necessitating advanced cardiac life support and percutaneous stellate ganglion blockade. Extracorporeal membrane oxygenation was considered, and arterial and venous small-bore sheaths were placed in order to allow for extracorporeal cardiopulmonary resuscitation if cardiac arrest recurred, but they were not ultimately used. She suffered an embolic left middle cerebral artery stroke but otherwise recovered from the episode. This eventful clinical course highlights the dangers of lacosamide in high doses. Cureus 2022-09-25 /pmc/articles/PMC9594684/ /pubmed/36312640 http://dx.doi.org/10.7759/cureus.29547 Text en Copyright © 2022, Marcellino et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Marcellino, Chris
Ransom, Chase C
Wijdicks, Eelco F
Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose
title Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose
title_full Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose
title_fullStr Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose
title_full_unstemmed Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose
title_short Refractory Ventricular Tachycardia and Seizures With Lacosamide Overdose
title_sort refractory ventricular tachycardia and seizures with lacosamide overdose
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594684/
https://www.ncbi.nlm.nih.gov/pubmed/36312640
http://dx.doi.org/10.7759/cureus.29547
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