Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans

AIMS: GITR—a co-stimulatory immune checkpoint protein—is known for both its activating and regulating effects on T-cells. As atherosclerosis bears features of chronic inflammation and autoimmunity, we investigated the relevance of GITR in cardiovascular disease (CVD). METHODS AND RESULTS: GITR expre...

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Detalles Bibliográficos
Autores principales: Shami, Annelie, Atzler, Dorothee, Bosmans, Laura A, Winkels, Holger, Meiler, Svenja, Lacy, Michael, van Tiel, Claudia, Ta Megens, Remco, Nitz, Katrin, Baardman, Jeroen, Kusters, Pascal, Seijkens, Tom, Buerger, Christina, Janjic, Aleksandar, Riccardi, Carlo, Edsfeldt, Andreas, Monaco, Claudia, Daemen, Mat, de Winther, Menno P J, Nilsson, Jan, Weber, Christian, Gerdes, Norbert, Gonçalves, Isabel, Lutgens, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594689/
https://www.ncbi.nlm.nih.gov/pubmed/32728688
http://dx.doi.org/10.1093/eurheartj/ehaa484

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