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Synonymous Codons and Hydrophobicity Optimization of Post-translational Signal Peptide PelB Increase Phage Display Efficiency of DARPins

[Image: see text] DsbA leader peptide targets proteins for cotranslational translocation by signal recognition particle (SRP) pathway and has been the standard signal sequence for filamentous phage display of fast-folding Designed Ankyrin Repeat Proteins (DARPins). In contrast, translocation of DARP...

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Detalles Bibliográficos
Autores principales: Kulmala, Antti, Lappalainen, Matias, Lamminmäki, Urpo, Huovinen, Tuomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594773/
https://www.ncbi.nlm.nih.gov/pubmed/36178799
http://dx.doi.org/10.1021/acssynbio.2c00260

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