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Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj

INTRODUCTION: In early 2021, Tunisia implemented a national COVID-19 strategy of vaccination aimed at disease elimination. In this study, we aimed to investigate the characteristics of the breakthrough COVID-19 infection in the governorate of Sousse, Tunisia. METHODOLOGY: We conducted a cross-sectio...

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Autores principales: Ben Fredj, S, Ghammem, R, Zammit, N, Maatouk, A, Hadded, N, Laadhari, H, Maatoug, J, Ghannem, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594833/
http://dx.doi.org/10.1093/eurpub/ckac131.098
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author Ben Fredj, S
Ghammem, R
Zammit, N
Maatouk, A
Hadded, N
Laadhari, H
Maatoug, J
Ghannem, H
author_facet Ben Fredj, S
Ghammem, R
Zammit, N
Maatouk, A
Hadded, N
Laadhari, H
Maatoug, J
Ghannem, H
author_sort Ben Fredj, S
collection PubMed
description INTRODUCTION: In early 2021, Tunisia implemented a national COVID-19 strategy of vaccination aimed at disease elimination. In this study, we aimed to investigate the characteristics of the breakthrough COVID-19 infection in the governorate of Sousse, Tunisia. METHODOLOGY: We conducted a cross-sectional study including all post-vaccination COVID-19 cases from March 2021 to August 2021. We collected data via 15-minute telephonic call interviews. We estimated the specific incidence rates (SIR) of confirmed cases by vaccine type and expressed them as cases per 100 000 inhabitants. Statistical analyzes were carried out using anonymous and codified Excel tables and SPSS 20. RESULTS: Overall, we included 618 cases of breakthrough COVID-19 infection. The majority were female (sex-ratio=0.8), and the average age of the overall cases was 55.7±14.5 years (range:19-91). Nearly half (49%) of participants had comorbidities, 19.6% were healthcare workers, and 17.9% were smokers. The majority of cases (70%) received at least one dose of Pfizer vaccine followed by CORONAVAC (15.6%; n = 96). Nevertheless, we found a higher incidence rate of COVID-19 among those vaccinated with SPUTNIK V (SIR=1551.2) followed by SINOPHARM (SIR=823.7). Fifty-eight percent of patients reported a poor adhesion to preventive measures, whereas 38.6% reported high respect for the preventive measures. COVID-19 infection led to hospitalization in 8.1% of cases, hospitalization in intensive care units in 2.1% of cases, and death in 1.8% of cases. CONCLUSIONS: The findings of our study highlight the low rate of severe cases of COVID-19 among the vaccinated population. Furthermore, we found a discrepancy in the effectiveness of vaccines in the prevention of transmission potential. Yet, many factors could influence the transmission and the severity of COVID-19 breakthrough infection from one region to another. KEY MESSAGES: • low rate of severe cases of COVID-19 among the vaccinated population. • discrepancy in the effectiveness of vaccines in the prevention of transmission potential.
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spelling pubmed-95948332022-11-04 Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj Ben Fredj, S Ghammem, R Zammit, N Maatouk, A Hadded, N Laadhari, H Maatoug, J Ghannem, H Eur J Public Health Poster Displays INTRODUCTION: In early 2021, Tunisia implemented a national COVID-19 strategy of vaccination aimed at disease elimination. In this study, we aimed to investigate the characteristics of the breakthrough COVID-19 infection in the governorate of Sousse, Tunisia. METHODOLOGY: We conducted a cross-sectional study including all post-vaccination COVID-19 cases from March 2021 to August 2021. We collected data via 15-minute telephonic call interviews. We estimated the specific incidence rates (SIR) of confirmed cases by vaccine type and expressed them as cases per 100 000 inhabitants. Statistical analyzes were carried out using anonymous and codified Excel tables and SPSS 20. RESULTS: Overall, we included 618 cases of breakthrough COVID-19 infection. The majority were female (sex-ratio=0.8), and the average age of the overall cases was 55.7±14.5 years (range:19-91). Nearly half (49%) of participants had comorbidities, 19.6% were healthcare workers, and 17.9% were smokers. The majority of cases (70%) received at least one dose of Pfizer vaccine followed by CORONAVAC (15.6%; n = 96). Nevertheless, we found a higher incidence rate of COVID-19 among those vaccinated with SPUTNIK V (SIR=1551.2) followed by SINOPHARM (SIR=823.7). Fifty-eight percent of patients reported a poor adhesion to preventive measures, whereas 38.6% reported high respect for the preventive measures. COVID-19 infection led to hospitalization in 8.1% of cases, hospitalization in intensive care units in 2.1% of cases, and death in 1.8% of cases. CONCLUSIONS: The findings of our study highlight the low rate of severe cases of COVID-19 among the vaccinated population. Furthermore, we found a discrepancy in the effectiveness of vaccines in the prevention of transmission potential. Yet, many factors could influence the transmission and the severity of COVID-19 breakthrough infection from one region to another. KEY MESSAGES: • low rate of severe cases of COVID-19 among the vaccinated population. • discrepancy in the effectiveness of vaccines in the prevention of transmission potential. Oxford University Press 2022-10-25 /pmc/articles/PMC9594833/ http://dx.doi.org/10.1093/eurpub/ckac131.098 Text en © The Author(s) 2022. Published by Oxford University Press on behalf of the European Public Health Association. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Poster Displays
Ben Fredj, S
Ghammem, R
Zammit, N
Maatouk, A
Hadded, N
Laadhari, H
Maatoug, J
Ghannem, H
Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj
title Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj
title_full Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj
title_fullStr Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj
title_full_unstemmed Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj
title_short Characteristics of COVID-19 cases with breakthrough infection in the governorate of Sousse, Tunisia: Sihem Ben Fredj
title_sort characteristics of covid-19 cases with breakthrough infection in the governorate of sousse, tunisia: sihem ben fredj
topic Poster Displays
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594833/
http://dx.doi.org/10.1093/eurpub/ckac131.098
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