Development of a modular photoreactor for the upscaling of continuous flow photochemistry

The upscaling of biphasic photochemical reactions is challenging because of the inherent constraints of liquid–gas mixing and light penetration. Using semi-permeable coaxial flow chemistry within a modular photoreactor, the photooxidation of the platform chemical furfural was scaled up to produce ro...

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Detalles Bibliográficos
Autores principales: Hermens, Johannes G. H., Lepage, Mathieu L., Kloekhorst, Arjan, Keller, Erik, Bloem, Robin, Meijer, Maurice, Feringa, Ben L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594834/
https://www.ncbi.nlm.nih.gov/pubmed/36352841
http://dx.doi.org/10.1039/d2re00310d
Descripción
Sumario:The upscaling of biphasic photochemical reactions is challenging because of the inherent constraints of liquid–gas mixing and light penetration. Using semi-permeable coaxial flow chemistry within a modular photoreactor, the photooxidation of the platform chemical furfural was scaled up to produce routinely 29 gram per day of biobased building block hydroxybutenolide, a precursor to acrylate alternatives.

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