Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1

BACKGROUND: Postmenopausal bone loss, mainly caused by excessive bone resorption mediated by osteoclasts, has become a global public health burden. Metformin, a hypoglycemic drug, has been reported to have beneficial effects on maintaining bone health. However, the role and underlying mechanism of m...

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Detalles Bibliográficos
Autores principales: Xie, Xudong, Hu, Liangcong, Mi, Bobin, Xue, Hang, Hu, Yiqiang, Panayi, Adriana C., Endo, Yori, Chen, Lang, Yan, Chenchen, Lin, Ze, Li, Hui, Zhou, Wu, Liu, Guohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9594975/
https://www.ncbi.nlm.nih.gov/pubmed/36284303
http://dx.doi.org/10.1186/s12964-022-00966-5

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