Cargando…

Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later

Translational validity (or trans-disciplinary validity) is defined as one possible approach to achieving incremental validity by combining simultaneous clinical state-dependent measures and functional MRI data acquisition. It is designed under the assumption that the simultaneous administration of t...

Descripción completa

Detalles Bibliográficos
Autor principal: Stoyanov, Drozdstoy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595022/
https://www.ncbi.nlm.nih.gov/pubmed/36304557
http://dx.doi.org/10.3389/fpsyt.2022.999680
_version_ 1784815552855801856
author Stoyanov, Drozdstoy
author_facet Stoyanov, Drozdstoy
author_sort Stoyanov, Drozdstoy
collection PubMed
description Translational validity (or trans-disciplinary validity) is defined as one possible approach to achieving incremental validity by combining simultaneous clinical state-dependent measures and functional MRI data acquisition. It is designed under the assumption that the simultaneous administration of the two methods may produce a dataset with enhanced synchronization and concordance. Translational validation aims at “bridging” the explanatory gap by implementing validated psychometric tools clinically in the experimental settings of fMRI and then translating them back to clinical utility. Our studies may have identified common diagnostic task-specific denominators in terms of activations and network modulation. However, those common denominators need further investigation to determine whether they signify disease or syndrome-specific features (signatures), which, at the end of the day, raises one more question about the poverty of current conventional psychiatric classification criteria. We propose herewith a novel algorithm for translational validation based on our explorative findings. The algorithm itself includes pre-selection of a test based on its psychometric characteristics, adaptation to the functional MRI paradigm, exploration of the underpinning whole brain neural correlates in healthy controls as compared to a patient population with certain diagnoses, and finally, investigation of the differences between two or more diagnostic classes.
format Online
Article
Text
id pubmed-9595022
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95950222022-10-26 Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later Stoyanov, Drozdstoy Front Psychiatry Psychiatry Translational validity (or trans-disciplinary validity) is defined as one possible approach to achieving incremental validity by combining simultaneous clinical state-dependent measures and functional MRI data acquisition. It is designed under the assumption that the simultaneous administration of the two methods may produce a dataset with enhanced synchronization and concordance. Translational validation aims at “bridging” the explanatory gap by implementing validated psychometric tools clinically in the experimental settings of fMRI and then translating them back to clinical utility. Our studies may have identified common diagnostic task-specific denominators in terms of activations and network modulation. However, those common denominators need further investigation to determine whether they signify disease or syndrome-specific features (signatures), which, at the end of the day, raises one more question about the poverty of current conventional psychiatric classification criteria. We propose herewith a novel algorithm for translational validation based on our explorative findings. The algorithm itself includes pre-selection of a test based on its psychometric characteristics, adaptation to the functional MRI paradigm, exploration of the underpinning whole brain neural correlates in healthy controls as compared to a patient population with certain diagnoses, and finally, investigation of the differences between two or more diagnostic classes. Frontiers Media S.A. 2022-10-10 /pmc/articles/PMC9595022/ /pubmed/36304557 http://dx.doi.org/10.3389/fpsyt.2022.999680 Text en Copyright © 2022 Stoyanov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Stoyanov, Drozdstoy
Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later
title Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later
title_full Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later
title_fullStr Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later
title_full_unstemmed Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later
title_short Perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional MRI in psychiatry: 10 years later
title_sort perspectives before incremental trans-disciplinary cross-validation of clinical self-evaluation tools and functional mri in psychiatry: 10 years later
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595022/
https://www.ncbi.nlm.nih.gov/pubmed/36304557
http://dx.doi.org/10.3389/fpsyt.2022.999680
work_keys_str_mv AT stoyanovdrozdstoy perspectivesbeforeincrementaltransdisciplinarycrossvalidationofclinicalselfevaluationtoolsandfunctionalmriinpsychiatry10yearslater