Modulation of the Estrogen/erbB2 Receptors Cross-talk by CDK4/6 Inhibition Triggers Sustained Senescence in Estrogen Receptor– and ErbB2-positive Breast Cancer

PURPOSE: The interplay between estrogen receptor (ER) and erbB tyrosine-kinase receptors (RTK) impacts growth and progression of ER-positive (ER(+))/HER2-positive (HER2(+)) breast cancer and generates mitogenic signals converging onto the Cyclin-D1/CDK4/6 complex. We probed this cross-talk combining...

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Detalles Bibliográficos
Autores principales: Viganò, Lucia, Locatelli, Alberta, Ulisse, Adele, Galbardi, Barbara, Dugo, Matteo, Tosi, Diego, Tacchetti, Carlo, Daniele, Tiziana, Győrffy, Balázs, Sica, Lorenzo, Macchini, Marina, Zambetti, Milvia, Zambelli, Stefania, Bianchini, Giampaolo, Gianni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595107/
https://www.ncbi.nlm.nih.gov/pubmed/35254385
http://dx.doi.org/10.1158/1078-0432.CCR-21-3185

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