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Silencing of proinflammatory NF-κB and inhibition of herpes simplex virus (HSV) replication by ultrasmall gold nanoparticles (2 nm) conjugated with small-interfering RNA

Azide-terminated ultrasmall gold nanoparticles (2 nm gold core) were covalently functionalized with alkyne-terminated small-interfering siRNA duplexes by copper-catalyzed azide–alkyne cycloaddition (CuAAC; click chemistry). The nanoparticle core was visualized by transmission electron microscopy. Th...

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Detalles Bibliográficos
Autores principales:	Wolff, Natalie, Kollenda, Sebastian, Klein, Kai, Loza, Kateryna, Heggen, Marc, Brochhagen, Leonie, Witzke, Oliver, Krawczyk, Adalbert, Hilger, Ingrid, Epple, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595109/ https://www.ncbi.nlm.nih.gov/pubmed/36341304 http://dx.doi.org/10.1039/d2na00250g

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