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A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment
An 18-year-old male presented with a single round to oval well-defined irregular erythematous plaque 10 cm × 6 cm, with a verrucous surface, central atrophy, and crusting at the periphery on the right knee of one-year duration. The patient had received ATT (anti-tubercular treatment) twice in the pa...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595161/ https://www.ncbi.nlm.nih.gov/pubmed/36304654 http://dx.doi.org/10.4103/idoj.idoj_76_22 |
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author | Khan, Farhat Nayak, Chitra S. Dongre, Atul Zambare, Uddhao |
author_facet | Khan, Farhat Nayak, Chitra S. Dongre, Atul Zambare, Uddhao |
author_sort | Khan, Farhat |
collection | PubMed |
description | An 18-year-old male presented with a single round to oval well-defined irregular erythematous plaque 10 cm × 6 cm, with a verrucous surface, central atrophy, and crusting at the periphery on the right knee of one-year duration. The patient had received ATT (anti-tubercular treatment) twice in the past without any improvement. MGIT (mycobacteria growth indicator tube) and CBNAAT (Cartridge-based nucleic acid amplification test) were performed, and drug sensitivity testing was done, which led to a diagnosis of multidrug resistance (MDR) with a mixed pattern. The management of cutaneous tuberculosis (TB) is becoming difficult due to an increase in resistance to category-I ATT. Patients harboring MDR and extensively drug-resistant (XDR) strains present a fearsome challenge for the clinician. A cure is possible with early identification of resistance and the use of an appropriate regimen. |
format | Online Article Text |
id | pubmed-9595161 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-95951612022-10-26 A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment Khan, Farhat Nayak, Chitra S. Dongre, Atul Zambare, Uddhao Indian Dermatol Online J Case Report An 18-year-old male presented with a single round to oval well-defined irregular erythematous plaque 10 cm × 6 cm, with a verrucous surface, central atrophy, and crusting at the periphery on the right knee of one-year duration. The patient had received ATT (anti-tubercular treatment) twice in the past without any improvement. MGIT (mycobacteria growth indicator tube) and CBNAAT (Cartridge-based nucleic acid amplification test) were performed, and drug sensitivity testing was done, which led to a diagnosis of multidrug resistance (MDR) with a mixed pattern. The management of cutaneous tuberculosis (TB) is becoming difficult due to an increase in resistance to category-I ATT. Patients harboring MDR and extensively drug-resistant (XDR) strains present a fearsome challenge for the clinician. A cure is possible with early identification of resistance and the use of an appropriate regimen. Wolters Kluwer - Medknow 2022-09-05 /pmc/articles/PMC9595161/ /pubmed/36304654 http://dx.doi.org/10.4103/idoj.idoj_76_22 Text en Copyright: © 2022 Indian Dermatology Online Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Khan, Farhat Nayak, Chitra S. Dongre, Atul Zambare, Uddhao A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment |
title | A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment |
title_full | A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment |
title_fullStr | A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment |
title_full_unstemmed | A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment |
title_short | A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment |
title_sort | rare case of multidrug-resistant lupus vulgaris with a mixed pattern of resistance – a long journey to diagnosis and treatment |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595161/ https://www.ncbi.nlm.nih.gov/pubmed/36304654 http://dx.doi.org/10.4103/idoj.idoj_76_22 |
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