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A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment

An 18-year-old male presented with a single round to oval well-defined irregular erythematous plaque 10 cm × 6 cm, with a verrucous surface, central atrophy, and crusting at the periphery on the right knee of one-year duration. The patient had received ATT (anti-tubercular treatment) twice in the pa...

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Autores principales: Khan, Farhat, Nayak, Chitra S., Dongre, Atul, Zambare, Uddhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595161/
https://www.ncbi.nlm.nih.gov/pubmed/36304654
http://dx.doi.org/10.4103/idoj.idoj_76_22
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author Khan, Farhat
Nayak, Chitra S.
Dongre, Atul
Zambare, Uddhao
author_facet Khan, Farhat
Nayak, Chitra S.
Dongre, Atul
Zambare, Uddhao
author_sort Khan, Farhat
collection PubMed
description An 18-year-old male presented with a single round to oval well-defined irregular erythematous plaque 10 cm × 6 cm, with a verrucous surface, central atrophy, and crusting at the periphery on the right knee of one-year duration. The patient had received ATT (anti-tubercular treatment) twice in the past without any improvement. MGIT (mycobacteria growth indicator tube) and CBNAAT (Cartridge-based nucleic acid amplification test) were performed, and drug sensitivity testing was done, which led to a diagnosis of multidrug resistance (MDR) with a mixed pattern. The management of cutaneous tuberculosis (TB) is becoming difficult due to an increase in resistance to category-I ATT. Patients harboring MDR and extensively drug-resistant (XDR) strains present a fearsome challenge for the clinician. A cure is possible with early identification of resistance and the use of an appropriate regimen.
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spelling pubmed-95951612022-10-26 A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment Khan, Farhat Nayak, Chitra S. Dongre, Atul Zambare, Uddhao Indian Dermatol Online J Case Report An 18-year-old male presented with a single round to oval well-defined irregular erythematous plaque 10 cm × 6 cm, with a verrucous surface, central atrophy, and crusting at the periphery on the right knee of one-year duration. The patient had received ATT (anti-tubercular treatment) twice in the past without any improvement. MGIT (mycobacteria growth indicator tube) and CBNAAT (Cartridge-based nucleic acid amplification test) were performed, and drug sensitivity testing was done, which led to a diagnosis of multidrug resistance (MDR) with a mixed pattern. The management of cutaneous tuberculosis (TB) is becoming difficult due to an increase in resistance to category-I ATT. Patients harboring MDR and extensively drug-resistant (XDR) strains present a fearsome challenge for the clinician. A cure is possible with early identification of resistance and the use of an appropriate regimen. Wolters Kluwer - Medknow 2022-09-05 /pmc/articles/PMC9595161/ /pubmed/36304654 http://dx.doi.org/10.4103/idoj.idoj_76_22 Text en Copyright: © 2022 Indian Dermatology Online Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Khan, Farhat
Nayak, Chitra S.
Dongre, Atul
Zambare, Uddhao
A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment
title A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment
title_full A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment
title_fullStr A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment
title_full_unstemmed A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment
title_short A Rare Case of Multidrug-Resistant Lupus Vulgaris with a Mixed Pattern of Resistance – A Long Journey to Diagnosis and Treatment
title_sort rare case of multidrug-resistant lupus vulgaris with a mixed pattern of resistance – a long journey to diagnosis and treatment
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595161/
https://www.ncbi.nlm.nih.gov/pubmed/36304654
http://dx.doi.org/10.4103/idoj.idoj_76_22
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