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Inhibition of the Aromatase Enzyme by Exemestane Cysteine Conjugates

Exemestane(EXE) is an aromatase inhibitor used to treat hormone-dependent breast cancer. EXE is extensively metabolized, with unchanged EXE and its active metabolite 17β-dihydroexemestane (17β-DHE) accounting for 17% and 12%, respectively, of total plasma EXE in vivo. The major circulating EXE metab...

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Detalles Bibliográficos
Autores principales:	Teslenko, Irina, Watson, Christy J.W., Chen, Gang, Lazarus, Philip
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595203/ https://www.ncbi.nlm.nih.gov/pubmed/35953090 http://dx.doi.org/10.1124/molpharm.122.000545

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