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An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature

Acinic cell carcinoma (ACC), previously called acinic cell tumor, is an uncommon malignant neoplasm that tends to recur locally without proper treatment measures. This low-grade neoplasm has four histological subtypes. We hereby report a case of a follicular variant of ACC, which is a rare subtype....

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Autores principales: Adhikary, Tamanna, Kumar, Harish, Mahapatra, Niva, Panda, Abikshyeet, Bhuyan, Lipsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595272/
https://www.ncbi.nlm.nih.gov/pubmed/36312662
http://dx.doi.org/10.7759/cureus.29559
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author Adhikary, Tamanna
Kumar, Harish
Mahapatra, Niva
Panda, Abikshyeet
Bhuyan, Lipsa
author_facet Adhikary, Tamanna
Kumar, Harish
Mahapatra, Niva
Panda, Abikshyeet
Bhuyan, Lipsa
author_sort Adhikary, Tamanna
collection PubMed
description Acinic cell carcinoma (ACC), previously called acinic cell tumor, is an uncommon malignant neoplasm that tends to recur locally without proper treatment measures. This low-grade neoplasm has four histological subtypes. We hereby report a case of a follicular variant of ACC, which is a rare subtype. A 20-year literature search encompassing this variant of ACC of the parotid region was also performed, which showed four reported cases. A 60-year-old woman reported to our college, Kalinga Institute of Dental Sciences, with the chief complaint of pain and swelling in her upper right back tooth region for the past three months. Upon incisional biopsy, histopathological examination revealed a follicular variant of ACC. Further, immunohistochemistry was also performed using markers such as DOG-1, CK7, S-100, and thyroglobulin, which showed CK7 marker positivity. Subtotal parotidectomy was performed and the tissue was sent for histopathological analysis. Although ACCs are slow-growing and indolent in character, they can frequently recur locally decades later and spread to distant organs. Long-term follow-up is necessary following therapy as ACC has a noticeably high propensity to relapse and create latent metastases.
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spelling pubmed-95952722022-10-28 An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature Adhikary, Tamanna Kumar, Harish Mahapatra, Niva Panda, Abikshyeet Bhuyan, Lipsa Cureus Pathology Acinic cell carcinoma (ACC), previously called acinic cell tumor, is an uncommon malignant neoplasm that tends to recur locally without proper treatment measures. This low-grade neoplasm has four histological subtypes. We hereby report a case of a follicular variant of ACC, which is a rare subtype. A 20-year literature search encompassing this variant of ACC of the parotid region was also performed, which showed four reported cases. A 60-year-old woman reported to our college, Kalinga Institute of Dental Sciences, with the chief complaint of pain and swelling in her upper right back tooth region for the past three months. Upon incisional biopsy, histopathological examination revealed a follicular variant of ACC. Further, immunohistochemistry was also performed using markers such as DOG-1, CK7, S-100, and thyroglobulin, which showed CK7 marker positivity. Subtotal parotidectomy was performed and the tissue was sent for histopathological analysis. Although ACCs are slow-growing and indolent in character, they can frequently recur locally decades later and spread to distant organs. Long-term follow-up is necessary following therapy as ACC has a noticeably high propensity to relapse and create latent metastases. Cureus 2022-09-25 /pmc/articles/PMC9595272/ /pubmed/36312662 http://dx.doi.org/10.7759/cureus.29559 Text en Copyright © 2022, Adhikary et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Adhikary, Tamanna
Kumar, Harish
Mahapatra, Niva
Panda, Abikshyeet
Bhuyan, Lipsa
An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature
title An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature
title_full An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature
title_fullStr An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature
title_full_unstemmed An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature
title_short An Exquisite Case Report of Follicular Variant of Acinic Cell Carcinoma of the Parotid Gland With Review of Literature
title_sort exquisite case report of follicular variant of acinic cell carcinoma of the parotid gland with review of literature
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595272/
https://www.ncbi.nlm.nih.gov/pubmed/36312662
http://dx.doi.org/10.7759/cureus.29559
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