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Hemodynamics-driven mathematical model of third heart sound generation

The proto-diastolic third heart sound (S3) is observed in various hemodynamic conditions in both normal and diseased hearts. We propose a novel, one-degree of freedom mathematical model of mechanical vibrations of heart and blood that generates the third heart sound, implemented in a real-time model...

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Autores principales: Shahmohammadi, Mehrdad, Huberts, Wouter, Luo, Hongxing, Westphal, Philip, Cornelussen, Richard N., Prinzen, Frits W., Delhaas, Tammo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595280/
https://www.ncbi.nlm.nih.gov/pubmed/36304577
http://dx.doi.org/10.3389/fphys.2022.847164
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author Shahmohammadi, Mehrdad
Huberts, Wouter
Luo, Hongxing
Westphal, Philip
Cornelussen, Richard N.
Prinzen, Frits W.
Delhaas, Tammo
author_facet Shahmohammadi, Mehrdad
Huberts, Wouter
Luo, Hongxing
Westphal, Philip
Cornelussen, Richard N.
Prinzen, Frits W.
Delhaas, Tammo
author_sort Shahmohammadi, Mehrdad
collection PubMed
description The proto-diastolic third heart sound (S3) is observed in various hemodynamic conditions in both normal and diseased hearts. We propose a novel, one-degree of freedom mathematical model of mechanical vibrations of heart and blood that generates the third heart sound, implemented in a real-time model of the cardiovascular system (CircAdapt). To examine model functionality, S3 simulations were performed for conditions mimicking the normal heart as well as heart failure with preserved ejection fraction (HFpEF), atrioventricular valve regurgitation (AVR), atrioventricular valve stenosis (AVS) and septal shunts (SS). Simulated S3 showed both qualitative and quantitative agreements with measured S3 in terms of morphology, frequency, and timing. It was shown that ventricular mass, ventricular viscoelastic properties as well as inflow momentum play a key role in the generation of S3. The model indicated that irrespective of cardiac conditions, S3 vibrations are always generated, in both the left and right sides of the heart, albeit at different levels of audibility. S3 intensities increased in HFpEF, AVR and SS, but the changes of acoustic S3 features in AVS were not significant, as compared with the reference simulation. S3 loudness in all simulated conditions was proportional to the level of cardiac output and severity of cardiac conditions. In conclusion, our hemodynamics-driven mathematical model provides a fast and realistic simulation of S3 under various conditions which may be helpful to find new indicators for diagnosis and prognosis of cardiac diseases.
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spelling pubmed-95952802022-10-26 Hemodynamics-driven mathematical model of third heart sound generation Shahmohammadi, Mehrdad Huberts, Wouter Luo, Hongxing Westphal, Philip Cornelussen, Richard N. Prinzen, Frits W. Delhaas, Tammo Front Physiol Physiology The proto-diastolic third heart sound (S3) is observed in various hemodynamic conditions in both normal and diseased hearts. We propose a novel, one-degree of freedom mathematical model of mechanical vibrations of heart and blood that generates the third heart sound, implemented in a real-time model of the cardiovascular system (CircAdapt). To examine model functionality, S3 simulations were performed for conditions mimicking the normal heart as well as heart failure with preserved ejection fraction (HFpEF), atrioventricular valve regurgitation (AVR), atrioventricular valve stenosis (AVS) and septal shunts (SS). Simulated S3 showed both qualitative and quantitative agreements with measured S3 in terms of morphology, frequency, and timing. It was shown that ventricular mass, ventricular viscoelastic properties as well as inflow momentum play a key role in the generation of S3. The model indicated that irrespective of cardiac conditions, S3 vibrations are always generated, in both the left and right sides of the heart, albeit at different levels of audibility. S3 intensities increased in HFpEF, AVR and SS, but the changes of acoustic S3 features in AVS were not significant, as compared with the reference simulation. S3 loudness in all simulated conditions was proportional to the level of cardiac output and severity of cardiac conditions. In conclusion, our hemodynamics-driven mathematical model provides a fast and realistic simulation of S3 under various conditions which may be helpful to find new indicators for diagnosis and prognosis of cardiac diseases. Frontiers Media S.A. 2022-10-11 /pmc/articles/PMC9595280/ /pubmed/36304577 http://dx.doi.org/10.3389/fphys.2022.847164 Text en Copyright © 2022 Shahmohammadi, Huberts, Luo, Westphal, Cornelussen, Prinzen and Delhaas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Shahmohammadi, Mehrdad
Huberts, Wouter
Luo, Hongxing
Westphal, Philip
Cornelussen, Richard N.
Prinzen, Frits W.
Delhaas, Tammo
Hemodynamics-driven mathematical model of third heart sound generation
title Hemodynamics-driven mathematical model of third heart sound generation
title_full Hemodynamics-driven mathematical model of third heart sound generation
title_fullStr Hemodynamics-driven mathematical model of third heart sound generation
title_full_unstemmed Hemodynamics-driven mathematical model of third heart sound generation
title_short Hemodynamics-driven mathematical model of third heart sound generation
title_sort hemodynamics-driven mathematical model of third heart sound generation
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595280/
https://www.ncbi.nlm.nih.gov/pubmed/36304577
http://dx.doi.org/10.3389/fphys.2022.847164
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