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Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses
OBJECTIVES: SARS-CoV-2 shedding has changed as new variants have emerged. It is important to understand the trajectory of PCR positivity due to Omicron in vaccinated populations. METHODS: Double- or triple-vaccinated adult household contacts of individuals with COVID-19 self-collected oral-nasal swa...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The British Infection Association. Published by Elsevier Ltd.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595488/ https://www.ncbi.nlm.nih.gov/pubmed/36283495 http://dx.doi.org/10.1016/j.jinf.2022.10.027 |
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author | Kandel, Christopher Lee, Yaejin Taylor, Maureen Llanes, Andrea McCready, Janine Crowl, Gloria Powis, Jeff Li, Angel Xinliu Shigayeva, Altynay Yip, Lily Katz, Kevin Kozak, Robert Mubareka, Samira McGeer, Allison |
author_facet | Kandel, Christopher Lee, Yaejin Taylor, Maureen Llanes, Andrea McCready, Janine Crowl, Gloria Powis, Jeff Li, Angel Xinliu Shigayeva, Altynay Yip, Lily Katz, Kevin Kozak, Robert Mubareka, Samira McGeer, Allison |
author_sort | Kandel, Christopher |
collection | PubMed |
description | OBJECTIVES: SARS-CoV-2 shedding has changed as new variants have emerged. It is important to understand the trajectory of PCR positivity due to Omicron in vaccinated populations. METHODS: Double- or triple-vaccinated adult household contacts of individuals with COVID-19 self-collected oral-nasal swabs for 14 days. A hierarchical linear model estimated viral load trajectories and an exploratory logistic regression model assessed for factors associated with viral detection before symptom onset. RESULTS: Forty-one participants developed COVID-19 with 37 (90%) symptomatic. Viral load peaked 3 days after symptom onset at a median concentration of 8.83 log(10) copies/milliliter (range 5.95–10.32) and the mean difference between participants with two or three COVID-19 vaccine doses was 0.02 log(10) copies/milliliter (95% CI -0.13 to 0.16). PCR positivity began with a range of 4 days prior to 3 days after symptom onset and was positive on the day of symptom onset in 76% (28/37). SARS-CoV-2 detection on the day of symptom onset was less likely among those with 2 vaccine doses (OR 0.13, 95%CI 0.02–0.79). 68% (25/37) of infected participants had detectable SARS-CoV-2 with Ct<30 at 7 days after symptom onset. CONCLUSIONS: Peak viral load and duration of PCR positivity were similar in participants with COVID-19 after two versus three COVID-19 vaccine doses. Onset of viral detection relative to symptom onset was variable. |
format | Online Article Text |
id | pubmed-9595488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The British Infection Association. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95954882022-10-25 Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses Kandel, Christopher Lee, Yaejin Taylor, Maureen Llanes, Andrea McCready, Janine Crowl, Gloria Powis, Jeff Li, Angel Xinliu Shigayeva, Altynay Yip, Lily Katz, Kevin Kozak, Robert Mubareka, Samira McGeer, Allison J Infect Article OBJECTIVES: SARS-CoV-2 shedding has changed as new variants have emerged. It is important to understand the trajectory of PCR positivity due to Omicron in vaccinated populations. METHODS: Double- or triple-vaccinated adult household contacts of individuals with COVID-19 self-collected oral-nasal swabs for 14 days. A hierarchical linear model estimated viral load trajectories and an exploratory logistic regression model assessed for factors associated with viral detection before symptom onset. RESULTS: Forty-one participants developed COVID-19 with 37 (90%) symptomatic. Viral load peaked 3 days after symptom onset at a median concentration of 8.83 log(10) copies/milliliter (range 5.95–10.32) and the mean difference between participants with two or three COVID-19 vaccine doses was 0.02 log(10) copies/milliliter (95% CI -0.13 to 0.16). PCR positivity began with a range of 4 days prior to 3 days after symptom onset and was positive on the day of symptom onset in 76% (28/37). SARS-CoV-2 detection on the day of symptom onset was less likely among those with 2 vaccine doses (OR 0.13, 95%CI 0.02–0.79). 68% (25/37) of infected participants had detectable SARS-CoV-2 with Ct<30 at 7 days after symptom onset. CONCLUSIONS: Peak viral load and duration of PCR positivity were similar in participants with COVID-19 after two versus three COVID-19 vaccine doses. Onset of viral detection relative to symptom onset was variable. The British Infection Association. Published by Elsevier Ltd. 2022-12 2022-10-22 /pmc/articles/PMC9595488/ /pubmed/36283495 http://dx.doi.org/10.1016/j.jinf.2022.10.027 Text en © 2022 The British Infection Association. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Kandel, Christopher Lee, Yaejin Taylor, Maureen Llanes, Andrea McCready, Janine Crowl, Gloria Powis, Jeff Li, Angel Xinliu Shigayeva, Altynay Yip, Lily Katz, Kevin Kozak, Robert Mubareka, Samira McGeer, Allison Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses |
title | Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses |
title_full | Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses |
title_fullStr | Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses |
title_full_unstemmed | Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses |
title_short | Viral dynamics of the SARS-CoV-2 Omicron Variant among household contacts with 2 or 3 COVID-19 vaccine doses |
title_sort | viral dynamics of the sars-cov-2 omicron variant among household contacts with 2 or 3 covid-19 vaccine doses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595488/ https://www.ncbi.nlm.nih.gov/pubmed/36283495 http://dx.doi.org/10.1016/j.jinf.2022.10.027 |
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