Cargando…

Inosine: A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storms constitute the primary cause of coronavirus disease 19 (COVID-19) progression, severity, criticality, and death. Glucocorticoid and anti-cytokine therapies are frequently administered to treat COVID-19, but have lim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ningning, Li, Entao, Deng, Huifang, Yue, Lanxin, Zhou, Lei, Su, Rina, He, Baokun, Lai, Chengcai, Li, Gaofu, Gao, Yuwei, Zhou, Wei, Gao, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Xi'an Jiaotong University 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595505/ https://www.ncbi.nlm.nih.gov/pubmed/36313960 http://dx.doi.org/10.1016/j.jpha.2022.10.002

Ejemplares similares

Quantification of Acipimox in Plasma and Tissues by LC–MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia
por: Shen, Xin, et al.
Publicado: (2022)

Targeting OPA1-Mediated Mitochondrial Fusion Contributed to Celastrol’s Anti-Tumor Angiogenesis Effect
por: Li, Gaofu, et al.
Publicado: (2022)

Inhibition of UBA6 by inosine augments tumour immunogenicity and responses
por: Zhang, Lei, et al.
Publicado: (2022)

Inhibition of miR-200b-3p confers broad-spectrum resistance to viral infection by targeting TBK1
por: Fang, An, et al.
Publicado: (2023)

Endothelial deletion of TBK1 contributes to BRB dysfunction via CXCR4 phosphorylation suppression
por: Zhao, Bowen, et al.
Publicado: (2022)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

Inosine in Biology and Disease
por: Srinivasan, Sundaramoorthy, et al.
Publicado: (2021)

Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1
por: Tsuchiya, Yuko, et al.
Publicado: (2016)

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β
por: Bakshi, Siddharth, et al.
Publicado: (2017)

TBK1 Limits mTORC1 by Promoting Phosphorylation of Raptor Ser877
por: Antonia, Ricardo J., et al.
Publicado: (2019)

Genotoxicity and Mutagenicity of Inosine Pranobex
por: Tobólska, Sylwia, et al.
Publicado: (2018)

Chicken infectious anemia virus (CIAV) VP1 antagonizes type I interferon (IFN-I) production by inhibiting TBK1 phosphorylation
por: Chen, Juncheng, et al.
Publicado: (2023)

PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
por: Li, Zexing, et al.
Publicado: (2015)

SPI-2/CrmA inhibits IFN-β induction by targeting TBK1/IKKε
por: Qin, Yue, et al.
Publicado: (2017)

Myeloid cell TBK1 restricts inflammatory responses
por: Gao, Tianxiao, et al.
Publicado: (2022)

Broadly Antiviral Activities of TAP1 through Activating the TBK1-IRF3-Mediated Type I Interferon Production
por: Zhao, Jin, et al.
Publicado: (2021)

TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation
por: Hu, Yi Wei, et al.
Publicado: (2018)

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway
por: Heo, J.-M., et al.
Publicado: (2018)

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation
por: Lafont, Elodie, et al.
Publicado: (2018)

HDAC6 Mediates Poly (I:C)-Induced TBK1 and Akt Phosphorylation in Macrophages
por: Wang, Yan, et al.
Publicado: (2020)

PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling
por: Lin, Yongfang, et al.
Publicado: (2023)

Inosine monophosphate dehydrogenase : a major therapeutic target /
Publicado: (2003)

The purine metabolite inosine monophosphate accelerates myelopoiesis and acute pancreatitis progression
por: Luo, Xiao-Min, et al.
Publicado: (2022)

The Advances of Broad-Spectrum and Hot Anti-Coronavirus Drugs
por: Zeng, Sen, et al.
Publicado: (2022)

Endonuclease V cleaves at inosines in RNA
por: Sebastian Vik, Erik, et al.
Publicado: (2013)

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
por: Walkley, Carl R., et al.
Publicado: (2017)

A novel TBK1 mutation in a family with diverse frontotemporal dementia spectrum disorders
por: Lamb, Ruth, et al.
Publicado: (2019)

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3
por: Lui, Pak-Yin, et al.
Publicado: (2016)

A Trim-RBD-GEM vaccine candidate protects mice from SARS-CoV-2
por: Su, Rina, et al.
Publicado: (2023)

DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation
por: An, Tai, et al.
Publicado: (2015)

Aphthous ulcer drug inhibits prostate tumor metastasis by targeting IKKɛ/TBK1/NF-κB signaling
por: Cheng, Chaping, et al.
Publicado: (2018)

FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees
por: Brenner, David, et al.
Publicado: (2021)

Adenosine-to-inosine RNA editing and human disease
por: Slotkin, William, et al.
Publicado: (2013)

Inosine in Neurodegenerative Diseases: From the Bench to the Bedside
por: Basile, Maria Sofia, et al.
Publicado: (2022)

ty-5 Confers Broad-Spectrum Resistance to Geminiviruses
por: Ren, Yanxiang, et al.
Publicado: (2022)

TBK1 Mutation Spectrum in an Extended European Patient Cohort with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
por: van der Zee, Julie, et al.
Publicado: (2017)

Identification of cellular microRNA miR-188-3p with broad-spectrum anti-influenza A virus activity
por: Cui, Huan, et al.
Publicado: (2020)

cGAS/STING/TBK1/IRF3 Signaling Pathway Activates BMDCs Maturation Following Mycobacterium bovis Infection
por: Li, Qiang, et al.
Publicado: (2019)

TBKBP1 and TBK1 form a growth factor signaling axis mediating immunosuppression and tumorigenesis
por: Zhu, Lele, et al.
Publicado: (2019)

Identification of Small GTPases That Phosphorylate IRF3 through TBK1 Activation Using an Active Mutant Library Screen
por: Yu, Jae-Hyun, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ul69hfr3l39d7ulfshmd6dohl7