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Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study
The complex effects of alcohol consumption on the cardiovascular system vary with mean daily consumption and duration of intake. This population-based retrospective cohort study aimed to explore the risk of cardiovascular disease (CVD) in patients with alcohol use disorder (AUD). Data was collected...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595521/ https://www.ncbi.nlm.nih.gov/pubmed/36282879 http://dx.doi.org/10.1371/journal.pone.0276690 |
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author | Sung, Chieh Chung, Chi-Hsiang Lin, Fu-Huang Chien, Wu-Chien Sun, Chien-An Tsao, Chang-Huei Weng, Chih-Erh |
author_facet | Sung, Chieh Chung, Chi-Hsiang Lin, Fu-Huang Chien, Wu-Chien Sun, Chien-An Tsao, Chang-Huei Weng, Chih-Erh |
author_sort | Sung, Chieh |
collection | PubMed |
description | The complex effects of alcohol consumption on the cardiovascular system vary with mean daily consumption and duration of intake. This population-based retrospective cohort study aimed to explore the risk of cardiovascular disease (CVD) in patients with alcohol use disorder (AUD). Data was collected from the Taiwan National Health Insurance Research Database from 2000 to 2013. A total of 7,420 patients with AUD were included in our study group, and 29,680 age- and sex-matched controls without AUD in the control group. Cox proportional hazard regression analysis was used to investigate the effects of AUD on the risk of CVD. Most patients were men aged 25–44 years. At the end of the follow-up period, the AUD group had a significantly higher incidence of CVD (27.39% vs. 19.97%, P<0.001) and more comorbidities than the control group. The AUD group also exhibited a significantly higher incidence of CVD than the control group based on the Cox regression analysis and Fine and Gray’s competing risk model (adjusted hazard ratio [AHR] = 1.447, 95% confidence interval [CI] = 1.372–1.52 5, P<0.001). Furthermore, male sex, diabetes mellitus, hypertension, hyperlipidemia, chronic kidney disease, chronic obstructive pulmonary disease, anxiety, depression, and a high Charlson Comorbidity Index were also associated with an increased risk of CVD. Patients with AUD in different CVD subgroups, such as those with CVD, ischemic heart disease (IHD), and stroke, were at a significantly higher risk of disease than those without AUD; CVD (AHR = 1.447, 95% CI = 1.372–1.525, P<0.001), IHD (AHR = 1.304, 95% CI = 1.214–1.401, P<0.001), and stroke (AHR = 1.640, 95% CI = 1.519–1.770, P<0.001). The risk also significantly differed among patients in the different CVD subgroups. We observed an association between AUD and development of CVD even after adjusting for several comorbidities and medications in our nationwide population cohort. |
format | Online Article Text |
id | pubmed-9595521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-95955212022-10-26 Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study Sung, Chieh Chung, Chi-Hsiang Lin, Fu-Huang Chien, Wu-Chien Sun, Chien-An Tsao, Chang-Huei Weng, Chih-Erh PLoS One Research Article The complex effects of alcohol consumption on the cardiovascular system vary with mean daily consumption and duration of intake. This population-based retrospective cohort study aimed to explore the risk of cardiovascular disease (CVD) in patients with alcohol use disorder (AUD). Data was collected from the Taiwan National Health Insurance Research Database from 2000 to 2013. A total of 7,420 patients with AUD were included in our study group, and 29,680 age- and sex-matched controls without AUD in the control group. Cox proportional hazard regression analysis was used to investigate the effects of AUD on the risk of CVD. Most patients were men aged 25–44 years. At the end of the follow-up period, the AUD group had a significantly higher incidence of CVD (27.39% vs. 19.97%, P<0.001) and more comorbidities than the control group. The AUD group also exhibited a significantly higher incidence of CVD than the control group based on the Cox regression analysis and Fine and Gray’s competing risk model (adjusted hazard ratio [AHR] = 1.447, 95% confidence interval [CI] = 1.372–1.52 5, P<0.001). Furthermore, male sex, diabetes mellitus, hypertension, hyperlipidemia, chronic kidney disease, chronic obstructive pulmonary disease, anxiety, depression, and a high Charlson Comorbidity Index were also associated with an increased risk of CVD. Patients with AUD in different CVD subgroups, such as those with CVD, ischemic heart disease (IHD), and stroke, were at a significantly higher risk of disease than those without AUD; CVD (AHR = 1.447, 95% CI = 1.372–1.525, P<0.001), IHD (AHR = 1.304, 95% CI = 1.214–1.401, P<0.001), and stroke (AHR = 1.640, 95% CI = 1.519–1.770, P<0.001). The risk also significantly differed among patients in the different CVD subgroups. We observed an association between AUD and development of CVD even after adjusting for several comorbidities and medications in our nationwide population cohort. Public Library of Science 2022-10-25 /pmc/articles/PMC9595521/ /pubmed/36282879 http://dx.doi.org/10.1371/journal.pone.0276690 Text en © 2022 Sung et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sung, Chieh Chung, Chi-Hsiang Lin, Fu-Huang Chien, Wu-Chien Sun, Chien-An Tsao, Chang-Huei Weng, Chih-Erh Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study |
title | Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study |
title_full | Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study |
title_fullStr | Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study |
title_full_unstemmed | Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study |
title_short | Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study |
title_sort | risk of cardiovascular disease in patients with alcohol use disorder: a population-based retrospective cohort study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595521/ https://www.ncbi.nlm.nih.gov/pubmed/36282879 http://dx.doi.org/10.1371/journal.pone.0276690 |
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