Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers

Chromosomal translocations are considered as one of the major causes of lymphoid cancers. RAG complex, which is responsible for V(D)J recombination, can also cleave non-B DNA structures and cryptic RSSs in the genome leading to chromosomal translocations. The mechanism and factors regulating the ill...

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Detalles Bibliográficos
Autores principales: Paranjape, Amita M., Desai, Sagar S., Nishana, Mayilaadumveettil, Roy, Urbi, Nilavar, Namrata M., Mondal, Amrita, Kumari, Rupa, Radha, Gudapureddy, Katapadi, Vijeth Kumar, Choudhary, Bibha, Raghavan, Sathees C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595545/
https://www.ncbi.nlm.nih.gov/pubmed/36228010
http://dx.doi.org/10.1371/journal.pgen.1010421

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