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Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review

Biological sex is an important risk factor for the occurrence and severity of infectious and parasitic diseases. Although various studies and reviews have described sex differences in infectious diseases of humans, wildlife and laboratory animals, there has been little focus on biological sex as a r...

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Autores principales: Byaruhanga, Charles, Knobel, Darryn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595549/
https://www.ncbi.nlm.nih.gov/pubmed/36282817
http://dx.doi.org/10.1371/journal.pone.0275578
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author Byaruhanga, Charles
Knobel, Darryn
author_facet Byaruhanga, Charles
Knobel, Darryn
author_sort Byaruhanga, Charles
collection PubMed
description Biological sex is an important risk factor for the occurrence and severity of infectious and parasitic diseases. Although various studies and reviews have described sex differences in infectious diseases of humans, wildlife and laboratory animals, there has been little focus on biological sex as a risk factor for infectious and parasitic diseases of domestic animals. We aim to identify and synthesise evidence in dogs for the hypothesis that biological sex and gonadectomy status are determinants of occurrence and severity of disease across taxa of pathogens. This systematic review follows the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines. We will search Web of Science, Scopus and PubMed for peer-reviewed studies published in English from database inception through 2021. All study designs for infectious and parasitic diseases of dogs will be included. This review will include the outcomes prevalence or incidence of infection or disease; and severity of disease as measured by case-fatality, time to death or recovery, hospitalisation time, pathogen burden (e.g. viral load or parasitaemia) or relevant clinicopathological parameters. Two reviewers will jointly assess the first 500 records from all three databases. Subsequently, one reviewer will screen the remaining records, and then the second reviewer will verify all records excluded by the first reviewer. Full-texts of all included records will be retrieved and assessed for eligibility by the first review author, and then the second author will review those records excluded by the first author. The risk of bias in individual studies will be assessed using the Risk of Bias Assessment tool for Nonrandomized Studies. We will synthesise the information from the studies and present this as a narrative in the text. The findings will be presented by outcome type and also grouped by pathogen type. Evidence on sex-specific effects will expand our understanding of infectious disease pathogenesis and underlying mechanisms, and this may be of importance in implementation of disease control interventions.
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spelling pubmed-95955492022-10-26 Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review Byaruhanga, Charles Knobel, Darryn PLoS One Study Protocol Biological sex is an important risk factor for the occurrence and severity of infectious and parasitic diseases. Although various studies and reviews have described sex differences in infectious diseases of humans, wildlife and laboratory animals, there has been little focus on biological sex as a risk factor for infectious and parasitic diseases of domestic animals. We aim to identify and synthesise evidence in dogs for the hypothesis that biological sex and gonadectomy status are determinants of occurrence and severity of disease across taxa of pathogens. This systematic review follows the Preferred Reporting Items for Systematic reviews and Meta-analyses (PRISMA) guidelines. We will search Web of Science, Scopus and PubMed for peer-reviewed studies published in English from database inception through 2021. All study designs for infectious and parasitic diseases of dogs will be included. This review will include the outcomes prevalence or incidence of infection or disease; and severity of disease as measured by case-fatality, time to death or recovery, hospitalisation time, pathogen burden (e.g. viral load or parasitaemia) or relevant clinicopathological parameters. Two reviewers will jointly assess the first 500 records from all three databases. Subsequently, one reviewer will screen the remaining records, and then the second reviewer will verify all records excluded by the first reviewer. Full-texts of all included records will be retrieved and assessed for eligibility by the first review author, and then the second author will review those records excluded by the first author. The risk of bias in individual studies will be assessed using the Risk of Bias Assessment tool for Nonrandomized Studies. We will synthesise the information from the studies and present this as a narrative in the text. The findings will be presented by outcome type and also grouped by pathogen type. Evidence on sex-specific effects will expand our understanding of infectious disease pathogenesis and underlying mechanisms, and this may be of importance in implementation of disease control interventions. Public Library of Science 2022-10-25 /pmc/articles/PMC9595549/ /pubmed/36282817 http://dx.doi.org/10.1371/journal.pone.0275578 Text en © 2022 Byaruhanga, Knobel https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Study Protocol
Byaruhanga, Charles
Knobel, Darryn
Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review
title Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review
title_full Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review
title_fullStr Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review
title_full_unstemmed Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review
title_short Sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: Protocol for a systematic review
title_sort sex as a risk factor for occurrence and severity of infectious and parasitic diseases in dogs: protocol for a systematic review
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595549/
https://www.ncbi.nlm.nih.gov/pubmed/36282817
http://dx.doi.org/10.1371/journal.pone.0275578
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