Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors

While genome editing has been revolutionized by the advent of CRISPR-based nucleases, difficulties in achieving efficient, nuclease-mediated, homology-directed repair (HDR) still limit many applications. Commonly used DNA donors such as plasmids suffer from low HDR efficiencies in many cell types, a...

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Detalles Bibliográficos
Autores principales: Iyer, Sukanya, Mir, Aamir, Vega-Badillo, Joel, Roscoe, Benjamin P., Ibraheim, Raed, Zhu, Lihua Julie, Lee, Jooyoung, Liu, Pengpeng, Luk, Kevin, Mintzer, Esther, Guo, Dongsheng, Soares de Brito, Josias, Emerson, Charles P., Zamore, Phillip D., Sontheimer, Erik J., Wolfe, Scot A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9595650/
https://www.ncbi.nlm.nih.gov/pubmed/36070530
http://dx.doi.org/10.1089/crispr.2022.0058

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