Continuous sensing of IFNα by hepatic endothelial cells shapes a vascular antimetastatic barrier

Hepatic metastases are a poor prognostic factor of colorectal carcinoma (CRC) and new strategies to reduce the risk of liver CRC colonization are highly needed. Herein, we used mouse models of hepatic metastatization to demonstrate that the continuous infusion of therapeutic doses of interferon-alph...

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Detalles Bibliográficos
Autores principales: Tran, Ngoc Lan, Ferreira, Lorena Maria, Alvarez-Moya, Blanca, Buttiglione, Valentina, Ferrini, Barbara, Zordan, Paola, Monestiroli, Andrea, Fagioli, Claudio, Bezzecchi, Eugenia, Scotti, Giulia Maria, Esposito, Antonio, Leone, Riccardo, Gnasso, Chiara, Brendolan, Andrea, Guidotti, Luca G, Sitia, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596162/
https://www.ncbi.nlm.nih.gov/pubmed/36281643
http://dx.doi.org/10.7554/eLife.80690

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