Cargando…
Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle
The aging of the immune system, or immunosenescence, was recently verified to have a causal role in driving the aging of solid organs, while the senolytic elimination of senescent immune cells was found to effectively delay systemic aging. Our recent study also showed that immune cells in severely d...
Autores principales: | Liu, Lei, Yue, Xianlin, Sun, Zewei, Hambright, William S., Feng, Qi, Cui, Yan, Huard, Johnny, Robbins, Paul D., Wang, Zhihui, Mu, Xiaodong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596208/ https://www.ncbi.nlm.nih.gov/pubmed/36084954 http://dx.doi.org/10.18632/aging.204275 |
Ejemplares similares
-
Reduction of senescent fibro‐adipogenic progenitors in progeria‐aged muscle by senolytics rescues the function of muscle stem cells
por: Liu, Lei, et al.
Publicado: (2022) -
Bioprinted Notch ligand to function as stem cell niche improves muscle regeneration in dystrophic muscle
por: Sun, Zewei, et al.
Publicado: (2023) -
Aberrant RhoA activation in macrophages increases senescence-associated secretory phenotypes and ectopic calcification in muscular dystrophic mice
por: Mu, Xiaodong, et al.
Publicado: (2020) -
Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence
por: Yue, Xianlin, et al.
Publicado: (2023) -
The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24(−/−) Progeria Mouse Model
por: Hambright, William S., et al.
Publicado: (2023)