Specific location of galactosylation in an afucosylated antiviral monoclonal antibody affects its FcγRIIIA binding affinity

Monoclonal antibodies (mAbs) comprise an essential type of biologic therapeutics and are used to treat diseases because of their anti-cancer and anti-inflammatory properties, and their ability to protect against respiratory infections. Its production involves post-translational glycosylation, a bios...

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Detalles Bibliográficos
Autores principales: Hatfield, Grayson, Tepliakova, Lioudmila, Gingras, Genevieve, Stalker, Andrew, Li, Xuguang, Aubin, Yves, Tam, Roger Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596277/
https://www.ncbi.nlm.nih.gov/pubmed/36304448
http://dx.doi.org/10.3389/fimmu.2022.972168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596277/
https://www.ncbi.nlm.nih.gov/pubmed/36304448
http://dx.doi.org/10.3389/fimmu.2022.972168

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