A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling

Interferons (IFNs) induce an antimicrobial state, protecting tissues from infection. Many viruses inhibit IFN signaling, but whether bacterial pathogens evade IFN responses remains unclear. Here, we demonstrate that the Shigella OspC family of type-III-secreted effectors blocks IFN signaling indepen...

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Detalles Bibliográficos
Autores principales: Alphonse, Noémie, Wanford, Joseph J., Voak, Andrew A., Gay, Jack, Venkhaya, Shayla, Burroughs, Owen, Mathew, Sanjana, Lee, Truelian, Evans, Sasha L., Zhao, Weiting, Frowde, Kyle, Alrehaili, Abrar, Dickenson, Ruth E., Munk, Mads, Panina, Svetlana, Mahmood, Ishraque F., Llorian, Miriam, Stanifer, Megan L., Boulant, Steeve, Berchtold, Martin W., Bergeron, Julien R.C., Wack, Andreas, Lesser, Cammie F., Odendall, Charlotte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596379/
https://www.ncbi.nlm.nih.gov/pubmed/35568036
http://dx.doi.org/10.1016/j.cell.2022.04.028

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