Treg-driven tumour control by PI3Kδ inhibition limits myeloid-derived suppressor cell expansion

BACKGROUND: Recent studies have demonstrated that blocking the PI3Kδ signalling enzyme (by administering a small molecule inhibitor, PI-3065) can potently improve the anti-tumour T-cell response through direct inhibition of Tregs. This treatment also has a negative impact on MDSC numbers but the pri...

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Detalles Bibliográficos
Autores principales: Lauder, Sarah N., Smart, Kathryn, Bart, Valentina M. T., Pires, Ana, Scott, Jake, Milutinovic, Stefan, Godkin, Andrew, Vanhaesebroeck, Bart, Gallimore, Awen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596434/
https://www.ncbi.nlm.nih.gov/pubmed/35986086
http://dx.doi.org/10.1038/s41416-022-01917-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596434/
https://www.ncbi.nlm.nih.gov/pubmed/35986086
http://dx.doi.org/10.1038/s41416-022-01917-0

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