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First hepatitis E outbreak in Southeastern Senegal

The Rapid proliferation of traditional gold mining sites in the Kedougou region has led to massive migration of people from neighbouring West African countries and the establishment of several small villages where poor hygiene and sanitation conditions exist. In this context, a Hepatitis E virus out...

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Autores principales: Sadio, Bacary Djilocalisse, Faye, Martin, Kaiser, Marco, Diarra, Maryam, Balique, Fanny, Diagne, Cheikh Tidiane, Faye, Oumar, Diagne, Moussa Moïse, Fall, Gamou, Ndiaye, Oumar, Loucoubar, Cheikh, Sow, Abdourahmane, Faye, Ousmane, Faye, Adama, Boye, Cheikh Saad Bouh, Sall, Amadou Alpha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596447/
https://www.ncbi.nlm.nih.gov/pubmed/36284151
http://dx.doi.org/10.1038/s41598-022-22491-8
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author Sadio, Bacary Djilocalisse
Faye, Martin
Kaiser, Marco
Diarra, Maryam
Balique, Fanny
Diagne, Cheikh Tidiane
Faye, Oumar
Diagne, Moussa Moïse
Fall, Gamou
Ndiaye, Oumar
Loucoubar, Cheikh
Sow, Abdourahmane
Faye, Ousmane
Faye, Adama
Boye, Cheikh Saad Bouh
Sall, Amadou Alpha
author_facet Sadio, Bacary Djilocalisse
Faye, Martin
Kaiser, Marco
Diarra, Maryam
Balique, Fanny
Diagne, Cheikh Tidiane
Faye, Oumar
Diagne, Moussa Moïse
Fall, Gamou
Ndiaye, Oumar
Loucoubar, Cheikh
Sow, Abdourahmane
Faye, Ousmane
Faye, Adama
Boye, Cheikh Saad Bouh
Sall, Amadou Alpha
author_sort Sadio, Bacary Djilocalisse
collection PubMed
description The Rapid proliferation of traditional gold mining sites in the Kedougou region has led to massive migration of people from neighbouring West African countries and the establishment of several small villages where poor hygiene and sanitation conditions exist. In this context, a Hepatitis E virus outbreak was reported in Kedougou in 2014 with several cases among the traditional mining workers. Herein, we described epidemiological and laboratory data collected during the outbreak’s investigation from February 2012 to November 2014. Any suspected, contact or probable case was investigated, clinical and epidemiological data were collected. In our study, sera were collected and tested for viral RNA and anti-Hepatitis E virus (HEV) IgM. Archived serum samples from Kedougou were retrospectively screened by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). A total of 65 water samples collected from ponds and wells surrounding gold panners' sites and habitats and 75 tissues samples from rats captured in the environment of traditional gold mining sites were also tested. A total of 1617 sera were collected from 698 suspected cases, 862 contacts and 57 persons with missing information. The median age was 20 (1–88 years-old) and the sex ratio was 1.72. An overall rate of 64.62% (1045/1617) of these patients tested positive for HEV with a high case fatality rate in pregnant women. All water samples and animal tissues tested negative for HEV. Our data help not only determining of the beginning of the HEV outbreak to March 2012, but also identifying risk factors associated to its emergence. However, there is a need to implement routine diagnosis, surveillance and training of health personnel in order to reduce mortality especially among pregnant women. In addition, further studies are needed to identify the virus reservoir and environmental risk factors for HEV in the Kedougou region.
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spelling pubmed-95964472022-10-27 First hepatitis E outbreak in Southeastern Senegal Sadio, Bacary Djilocalisse Faye, Martin Kaiser, Marco Diarra, Maryam Balique, Fanny Diagne, Cheikh Tidiane Faye, Oumar Diagne, Moussa Moïse Fall, Gamou Ndiaye, Oumar Loucoubar, Cheikh Sow, Abdourahmane Faye, Ousmane Faye, Adama Boye, Cheikh Saad Bouh Sall, Amadou Alpha Sci Rep Article The Rapid proliferation of traditional gold mining sites in the Kedougou region has led to massive migration of people from neighbouring West African countries and the establishment of several small villages where poor hygiene and sanitation conditions exist. In this context, a Hepatitis E virus outbreak was reported in Kedougou in 2014 with several cases among the traditional mining workers. Herein, we described epidemiological and laboratory data collected during the outbreak’s investigation from February 2012 to November 2014. Any suspected, contact or probable case was investigated, clinical and epidemiological data were collected. In our study, sera were collected and tested for viral RNA and anti-Hepatitis E virus (HEV) IgM. Archived serum samples from Kedougou were retrospectively screened by real-time polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). A total of 65 water samples collected from ponds and wells surrounding gold panners' sites and habitats and 75 tissues samples from rats captured in the environment of traditional gold mining sites were also tested. A total of 1617 sera were collected from 698 suspected cases, 862 contacts and 57 persons with missing information. The median age was 20 (1–88 years-old) and the sex ratio was 1.72. An overall rate of 64.62% (1045/1617) of these patients tested positive for HEV with a high case fatality rate in pregnant women. All water samples and animal tissues tested negative for HEV. Our data help not only determining of the beginning of the HEV outbreak to March 2012, but also identifying risk factors associated to its emergence. However, there is a need to implement routine diagnosis, surveillance and training of health personnel in order to reduce mortality especially among pregnant women. In addition, further studies are needed to identify the virus reservoir and environmental risk factors for HEV in the Kedougou region. Nature Publishing Group UK 2022-10-25 /pmc/articles/PMC9596447/ /pubmed/36284151 http://dx.doi.org/10.1038/s41598-022-22491-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Sadio, Bacary Djilocalisse
Faye, Martin
Kaiser, Marco
Diarra, Maryam
Balique, Fanny
Diagne, Cheikh Tidiane
Faye, Oumar
Diagne, Moussa Moïse
Fall, Gamou
Ndiaye, Oumar
Loucoubar, Cheikh
Sow, Abdourahmane
Faye, Ousmane
Faye, Adama
Boye, Cheikh Saad Bouh
Sall, Amadou Alpha
First hepatitis E outbreak in Southeastern Senegal
title First hepatitis E outbreak in Southeastern Senegal
title_full First hepatitis E outbreak in Southeastern Senegal
title_fullStr First hepatitis E outbreak in Southeastern Senegal
title_full_unstemmed First hepatitis E outbreak in Southeastern Senegal
title_short First hepatitis E outbreak in Southeastern Senegal
title_sort first hepatitis e outbreak in southeastern senegal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596447/
https://www.ncbi.nlm.nih.gov/pubmed/36284151
http://dx.doi.org/10.1038/s41598-022-22491-8
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