Pooled image-base screening of mitochondria with microraft isolation distinguishes pathogenic mitofusin 2 mutations

Most human genetic variation is classified as variants of uncertain significance. While advances in genome editing have allowed innovation in pooled screening platforms, many screens deal with relatively simple readouts (viability, fluorescence) and cannot identify the complex cellular phenotypes th...

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Detalles Bibliográficos
Autores principales: Yenkin, Alex L., Bramley, John C., Kremitzki, Colin L., Waligorski, Jason E., Liebeskind, Mariel J., Xu, Xinyuan E., Chandrasekaran, Vinay D., Vakaki, Maria A., Bachman, Graham W., Mitra, Robi D., Milbrandt, Jeffrey D., Buchser, William J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596453/
https://www.ncbi.nlm.nih.gov/pubmed/36284160
http://dx.doi.org/10.1038/s42003-022-04089-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596453/
https://www.ncbi.nlm.nih.gov/pubmed/36284160
http://dx.doi.org/10.1038/s42003-022-04089-y

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