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A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada
Health technology assessment (HTA) can be used to make healthcare systems more equitable and efficient. Advances in precision oncology are challenging conventional thinking about HTA. Precision oncology advances are rapid, involve small patient groups, and are frequently evaluated without a randomiz...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596463/ https://www.ncbi.nlm.nih.gov/pubmed/36284134 http://dx.doi.org/10.1038/s41698-022-00316-1 |
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author | Regier, Dean A. Pollard, Samantha McPhail, Melanie Bubela, Tania Hanna, Timothy P. Ho, Cheryl Lim, Howard J. Chan, Kelvin Peacock, Stuart J. Weymann, Deirdre |
author_facet | Regier, Dean A. Pollard, Samantha McPhail, Melanie Bubela, Tania Hanna, Timothy P. Ho, Cheryl Lim, Howard J. Chan, Kelvin Peacock, Stuart J. Weymann, Deirdre |
author_sort | Regier, Dean A. |
collection | PubMed |
description | Health technology assessment (HTA) can be used to make healthcare systems more equitable and efficient. Advances in precision oncology are challenging conventional thinking about HTA. Precision oncology advances are rapid, involve small patient groups, and are frequently evaluated without a randomized comparison group. In light of these challenges, mechanisms to manage precision oncology uncertainties are critical. We propose a life-cycle HTA framework and outline supporting criteria to manage uncertainties based on real world data collected from learning healthcare systems. If appropriately designed, we argue that life-cycle HTA is the driver of real world evidence generation and furthers our understanding of comparative effectiveness and value. We conclude that life-cycle HTA deliberation processes must be embedded into healthcare systems for an agile response to the constantly changing landscape of precision oncology innovation. We encourage further research outlining the core requirements, infrastructure, and checklists needed to achieve the goal of learning healthcare supporting life-cycle HTA. |
format | Online Article Text |
id | pubmed-9596463 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-95964632022-10-27 A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada Regier, Dean A. Pollard, Samantha McPhail, Melanie Bubela, Tania Hanna, Timothy P. Ho, Cheryl Lim, Howard J. Chan, Kelvin Peacock, Stuart J. Weymann, Deirdre NPJ Precis Oncol Perspective Health technology assessment (HTA) can be used to make healthcare systems more equitable and efficient. Advances in precision oncology are challenging conventional thinking about HTA. Precision oncology advances are rapid, involve small patient groups, and are frequently evaluated without a randomized comparison group. In light of these challenges, mechanisms to manage precision oncology uncertainties are critical. We propose a life-cycle HTA framework and outline supporting criteria to manage uncertainties based on real world data collected from learning healthcare systems. If appropriately designed, we argue that life-cycle HTA is the driver of real world evidence generation and furthers our understanding of comparative effectiveness and value. We conclude that life-cycle HTA deliberation processes must be embedded into healthcare systems for an agile response to the constantly changing landscape of precision oncology innovation. We encourage further research outlining the core requirements, infrastructure, and checklists needed to achieve the goal of learning healthcare supporting life-cycle HTA. Nature Publishing Group UK 2022-10-25 /pmc/articles/PMC9596463/ /pubmed/36284134 http://dx.doi.org/10.1038/s41698-022-00316-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Perspective Regier, Dean A. Pollard, Samantha McPhail, Melanie Bubela, Tania Hanna, Timothy P. Ho, Cheryl Lim, Howard J. Chan, Kelvin Peacock, Stuart J. Weymann, Deirdre A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada |
title | A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada |
title_full | A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada |
title_fullStr | A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada |
title_full_unstemmed | A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada |
title_short | A perspective on life-cycle health technology assessment and real-world evidence for precision oncology in Canada |
title_sort | perspective on life-cycle health technology assessment and real-world evidence for precision oncology in canada |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596463/ https://www.ncbi.nlm.nih.gov/pubmed/36284134 http://dx.doi.org/10.1038/s41698-022-00316-1 |
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