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Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from tumour cells reduce the efficacy of conventional cancer treatment paradigms and contribute to tumour progression and metastas...

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Autores principales: Zhang, Tianyi, Ren, Yanxian, Yang, Pengfei, Wang, Jufang, Zhou, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596464/
https://www.ncbi.nlm.nih.gov/pubmed/36284087
http://dx.doi.org/10.1038/s41419-022-05351-1
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author Zhang, Tianyi
Ren, Yanxian
Yang, Pengfei
Wang, Jufang
Zhou, Heng
author_facet Zhang, Tianyi
Ren, Yanxian
Yang, Pengfei
Wang, Jufang
Zhou, Heng
author_sort Zhang, Tianyi
collection PubMed
description Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from tumour cells reduce the efficacy of conventional cancer treatment paradigms and contribute to tumour progression and metastasis. As abundant tumour-promoting cells in the ECM, cancer-associated fibroblasts (CAFs) are promising targets for novel anti-tumour interventions. Nonetheless, related clinical trials are hampered by the lack of specific markers and elusive differences between CAF subtypes. Here, we review the origins and functional diversity of CAFs and show how they create a tumour-promoting milieu, focusing on the crosstalk between CAFs, tumour cells, and immune cells in the tumour microenvironment. Furthermore, relevant clinical advances and potential therapeutic strategies relating to CAFs are discussed.
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spelling pubmed-95964642022-10-27 Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma Zhang, Tianyi Ren, Yanxian Yang, Pengfei Wang, Jufang Zhou, Heng Cell Death Dis Review Article Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from tumour cells reduce the efficacy of conventional cancer treatment paradigms and contribute to tumour progression and metastasis. As abundant tumour-promoting cells in the ECM, cancer-associated fibroblasts (CAFs) are promising targets for novel anti-tumour interventions. Nonetheless, related clinical trials are hampered by the lack of specific markers and elusive differences between CAF subtypes. Here, we review the origins and functional diversity of CAFs and show how they create a tumour-promoting milieu, focusing on the crosstalk between CAFs, tumour cells, and immune cells in the tumour microenvironment. Furthermore, relevant clinical advances and potential therapeutic strategies relating to CAFs are discussed. Nature Publishing Group UK 2022-10-25 /pmc/articles/PMC9596464/ /pubmed/36284087 http://dx.doi.org/10.1038/s41419-022-05351-1 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Zhang, Tianyi
Ren, Yanxian
Yang, Pengfei
Wang, Jufang
Zhou, Heng
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
title Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
title_full Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
title_fullStr Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
title_full_unstemmed Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
title_short Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
title_sort cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596464/
https://www.ncbi.nlm.nih.gov/pubmed/36284087
http://dx.doi.org/10.1038/s41419-022-05351-1
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