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Intestine-specific removal of DAF-2 nearly doubles lifespan in Caenorhabditis elegans with little fitness cost

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2 doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 receptor gene is expressed and where it acts to regulate ageing. Using knock-in fluorescent reporters, we determined that d...

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Detalles Bibliográficos
Autores principales:	Zhang, Yan-Ping, Zhang, Wen-Hong, Zhang, Pan, Li, Qi, Sun, Yue, Wang, Jia-Wen, Zhang, Shaobing O., Cai, Tao, Zhan, Cheng, Dong, Meng-Qiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596710/ https://www.ncbi.nlm.nih.gov/pubmed/36284093 http://dx.doi.org/10.1038/s41467-022-33850-4

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