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The two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons
Maintaining genomic integrity in post-mitotic neurons in the human brain is paramount because these cells must survive for an individual’s entire lifespan. Due to life-long synaptic plasticity and electrochemical transmission between cells, the brain engages in an exceptionally high level of mitocho...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596766/ https://www.ncbi.nlm.nih.gov/pubmed/36313183 http://dx.doi.org/10.3389/fragi.2022.991460 |