Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations

We provide follow-up data on the humoral immune response after COVID-19 vaccinations of two distinct cohorts aged below 60 and over 80 years to screen for age-related differences in the longevity and magnitude of the induction of the antibody responses post booster-vaccinations. While anti-SARS-CoV-...

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Autores principales: Müller, Lisa, Andrée, Marcel, Moskorz, Wiebke, Drexler, Ingo, Hauka, Sandra, Ptok, Johannes, Walotka, Lara, Grothmann, Ramona, Hillebrandt, Jonas, Ritchie, Anastasia, Peter, Laura, Walker, Andreas, Timm, Jörg, Adams, Ortwin, Schaal, Heiner
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Aging
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596780/
https://www.ncbi.nlm.nih.gov/pubmed/36313184
http://dx.doi.org/10.3389/fragi.2022.1027885
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author Müller, Lisa
Andrée, Marcel
Moskorz, Wiebke
Drexler, Ingo
Hauka, Sandra
Ptok, Johannes
Walotka, Lara
Grothmann, Ramona
Hillebrandt, Jonas
Ritchie, Anastasia
Peter, Laura
Walker, Andreas
Timm, Jörg
Adams, Ortwin
Schaal, Heiner
author_facet Müller, Lisa
Andrée, Marcel
Moskorz, Wiebke
Drexler, Ingo
Hauka, Sandra
Ptok, Johannes
Walotka, Lara
Grothmann, Ramona
Hillebrandt, Jonas
Ritchie, Anastasia
Peter, Laura
Walker, Andreas
Timm, Jörg
Adams, Ortwin
Schaal, Heiner
author_sort Müller, Lisa
collection PubMed
description We provide follow-up data on the humoral immune response after COVID-19 vaccinations of two distinct cohorts aged below 60 and over 80 years to screen for age-related differences in the longevity and magnitude of the induction of the antibody responses post booster-vaccinations. While anti-SARS-CoV-2 spike-specific IgG and neutralization capacity waned rapidly after the initial vaccination schedule, additional boosters highly benefitted the humoral immune responses especially in the elderly cohort, including the neutralization of Omikron variants. Thus, adjusted COVID-19 booster vaccination schedules are an appropriate tool to overcome limitations in the success of vaccinations.
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spelling pubmed-95967802022-10-27 Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations Müller, Lisa Andrée, Marcel Moskorz, Wiebke Drexler, Ingo Hauka, Sandra Ptok, Johannes Walotka, Lara Grothmann, Ramona Hillebrandt, Jonas Ritchie, Anastasia Peter, Laura Walker, Andreas Timm, Jörg Adams, Ortwin Schaal, Heiner Front Aging Aging We provide follow-up data on the humoral immune response after COVID-19 vaccinations of two distinct cohorts aged below 60 and over 80 years to screen for age-related differences in the longevity and magnitude of the induction of the antibody responses post booster-vaccinations. While anti-SARS-CoV-2 spike-specific IgG and neutralization capacity waned rapidly after the initial vaccination schedule, additional boosters highly benefitted the humoral immune responses especially in the elderly cohort, including the neutralization of Omikron variants. Thus, adjusted COVID-19 booster vaccination schedules are an appropriate tool to overcome limitations in the success of vaccinations. Frontiers Media S.A. 2022-10-12 /pmc/articles/PMC9596780/ /pubmed/36313184 http://dx.doi.org/10.3389/fragi.2022.1027885 Text en Copyright © 2022 Müller, Andrée, Moskorz, Drexler, Hauka, Ptok, Walotka, Grothmann, Hillebrandt, Ritchie, Peter, Walker, Timm, Adams and Schaal. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Müller, Lisa
Andrée, Marcel
Moskorz, Wiebke
Drexler, Ingo
Hauka, Sandra
Ptok, Johannes
Walotka, Lara
Grothmann, Ramona
Hillebrandt, Jonas
Ritchie, Anastasia
Peter, Laura
Walker, Andreas
Timm, Jörg
Adams, Ortwin
Schaal, Heiner
Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
title Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
title_full Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
title_fullStr Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
title_full_unstemmed Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
title_short Adjusted COVID-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
title_sort adjusted covid-19 booster schedules balance age-dependent differences in antibody titers benefitting risk populations
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596780/
https://www.ncbi.nlm.nih.gov/pubmed/36313184
http://dx.doi.org/10.3389/fragi.2022.1027885
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