Biphasic cell cycle defect causes impaired neurogenesis in down syndrome

Impaired neurogenesis in Down syndrome (DS) is characterized by reduced neurons, increased glial cells, and delayed cortical lamination. However, the underlying cause for impaired neurogenesis in DS is not clear. Using both human and mouse iPSCs, we demonstrate that DS impaired neurogenesis is due t...

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Detalles Bibliográficos
Autores principales: Sharma, Vishi, Nehra, Sunita, Do, Long H., Ghosh, Anwesha, Deshpande, Aniruddha J., Singhal, Nishant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596798/
https://www.ncbi.nlm.nih.gov/pubmed/36313423
http://dx.doi.org/10.3389/fgene.2022.1007519

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