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Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR‐Mediated Base Editors

Selective inhibition of targeted protein kinases is an effective therapeutic approach for treatment of human malignancies, which interferes phosphorylation of cellular substrates. However, a drug‐imposed selection creates pressures for tumor cells to acquire chemoresistance‐conferring mutations or a...

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Detalles Bibliográficos
Autores principales: Li, Jianan, Lin, Jianxiang, Huang, Shisheng, Li, Min, Yu, Wenxia, Zhao, Yuting, Guo, Junfan, Zhang, Pumin, Huang, Xingxu, Qiao, Yunbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596822/
https://www.ncbi.nlm.nih.gov/pubmed/36045417
http://dx.doi.org/10.1002/advs.202200717