A novel anti-atherosclerotic mechanism of quercetin: Competitive binding to KEAP1 via Arg483 to inhibit macrophage pyroptosis

Natural antioxidants represented by quercetin have been documented to be effective against atherosclerosis. However, the related mechanisms remain largely unclear. In this study, we identified a novel anti-atherosclerotic mechanism of quercetin inhibiting macrophage pyroptosis by activating NRF2 thr...

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Detalles Bibliográficos
Autores principales: Luo, Xing, Weng, Xiuzhu, Bao, Xiaoyi, Bai, Xiaoxuan, Lv, Ying, Zhang, Shan, Chen, Yuwu, Zhao, Chen, Zeng, Ming, Huang, Jianxin, Xu, Biyi, Johnson, Thomas W., White, Stephen J., Li, Ji, Jia, Haibo, Yu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596875/
https://www.ncbi.nlm.nih.gov/pubmed/36274522
http://dx.doi.org/10.1016/j.redox.2022.102511

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