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Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer

OBJECTIVE: This study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene (POLE) in endometrial cancer (EC) and to investigate the effects of EDMs on tumor cell behavior and catalytic activities of Polϵ. METHODS: POLE sequencing was performed in tumor tissue...

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Detalles Bibliográficos
Autores principales:	Tian, Wenjuan, Ji, Zhaodong, Wang, Jingshu, Meng, Jiao, Bi, Rui, Ren, Yulan, Shan, Boer, Yang, Gong, Wang, Huaying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9596989/ https://www.ncbi.nlm.nih.gov/pubmed/36313640 http://dx.doi.org/10.3389/fonc.2022.1018034

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