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Fasting blood glucose as a predictor of progressive infarction in men with acute ischemic stroke
OBJECTIVE: Blood glucose is related to early neurological deterioration in acute ischemic stroke, but multiple mechanisms are involved in early neurological deterioration, such as progressive infarction. This study aimed to determine whether fasting blood glucose (FBG) is an independent predictor of...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597044/ https://www.ncbi.nlm.nih.gov/pubmed/36271599 http://dx.doi.org/10.1177/03000605221132416 |
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author | Yu, Qiulong Mao, Xiaocheng Fu, Zhihui Luo, Si Huang, Qin Chen, Qianxi Li, Shumeng Zhang, Jinchong Qiu, Yuexin Wu, Yuhang Fang, Pu Hong, Daojun Lin, Jing |
author_facet | Yu, Qiulong Mao, Xiaocheng Fu, Zhihui Luo, Si Huang, Qin Chen, Qianxi Li, Shumeng Zhang, Jinchong Qiu, Yuexin Wu, Yuhang Fang, Pu Hong, Daojun Lin, Jing |
author_sort | Yu, Qiulong |
collection | PubMed |
description | OBJECTIVE: Blood glucose is related to early neurological deterioration in acute ischemic stroke, but multiple mechanisms are involved in early neurological deterioration, such as progressive infarction. This study aimed to determine whether fasting blood glucose (FBG) is an independent predictor of progressive infarction. METHODS: From April 2017 to December 2020, we retrospectively enrolled 477 patients with acute ischemic stroke within 48 hours of onset. Demographic characteristics, clinical information, neuroimaging characteristics, and laboratory data were collected after admission. RESULTS: We found that 147 (30.8%) patients had progressive infarction. Multiple regression analysis showed that high FBG concentrations (>7.66 mmol/L) were independently associated with progressive infarction. Sex subgroup analysis showed that high FBG concentrations were an independent predictor of progressive infarction in male patients (odds ratio, 2.559; 95% confidence interval, 1.279–5.121). In a receiver operating characteristic curve analysis, FBG concentrations were a predictor of progressive infarction in all cases, especially in male patients. The cutoff value of FBG in all patients and men was 7.155 mmol/L. CONCLUSIONS: FBG is an independent predictor of progressive infarction in patients with acute ischemic stroke within 48 hours of onset, especially in men. Patients with FBG concentrations ≥7.155 mmol/L are more likely to develop progressive infarction. |
format | Online Article Text |
id | pubmed-9597044 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-95970442022-10-27 Fasting blood glucose as a predictor of progressive infarction in men with acute ischemic stroke Yu, Qiulong Mao, Xiaocheng Fu, Zhihui Luo, Si Huang, Qin Chen, Qianxi Li, Shumeng Zhang, Jinchong Qiu, Yuexin Wu, Yuhang Fang, Pu Hong, Daojun Lin, Jing J Int Med Res Retrospective Clinical Research Report OBJECTIVE: Blood glucose is related to early neurological deterioration in acute ischemic stroke, but multiple mechanisms are involved in early neurological deterioration, such as progressive infarction. This study aimed to determine whether fasting blood glucose (FBG) is an independent predictor of progressive infarction. METHODS: From April 2017 to December 2020, we retrospectively enrolled 477 patients with acute ischemic stroke within 48 hours of onset. Demographic characteristics, clinical information, neuroimaging characteristics, and laboratory data were collected after admission. RESULTS: We found that 147 (30.8%) patients had progressive infarction. Multiple regression analysis showed that high FBG concentrations (>7.66 mmol/L) were independently associated with progressive infarction. Sex subgroup analysis showed that high FBG concentrations were an independent predictor of progressive infarction in male patients (odds ratio, 2.559; 95% confidence interval, 1.279–5.121). In a receiver operating characteristic curve analysis, FBG concentrations were a predictor of progressive infarction in all cases, especially in male patients. The cutoff value of FBG in all patients and men was 7.155 mmol/L. CONCLUSIONS: FBG is an independent predictor of progressive infarction in patients with acute ischemic stroke within 48 hours of onset, especially in men. Patients with FBG concentrations ≥7.155 mmol/L are more likely to develop progressive infarction. SAGE Publications 2022-10-21 /pmc/articles/PMC9597044/ /pubmed/36271599 http://dx.doi.org/10.1177/03000605221132416 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Retrospective Clinical Research Report Yu, Qiulong Mao, Xiaocheng Fu, Zhihui Luo, Si Huang, Qin Chen, Qianxi Li, Shumeng Zhang, Jinchong Qiu, Yuexin Wu, Yuhang Fang, Pu Hong, Daojun Lin, Jing Fasting blood glucose as a predictor of progressive infarction in men with acute ischemic stroke |
title | Fasting blood glucose as a predictor of progressive infarction in men
with acute ischemic stroke |
title_full | Fasting blood glucose as a predictor of progressive infarction in men
with acute ischemic stroke |
title_fullStr | Fasting blood glucose as a predictor of progressive infarction in men
with acute ischemic stroke |
title_full_unstemmed | Fasting blood glucose as a predictor of progressive infarction in men
with acute ischemic stroke |
title_short | Fasting blood glucose as a predictor of progressive infarction in men
with acute ischemic stroke |
title_sort | fasting blood glucose as a predictor of progressive infarction in men
with acute ischemic stroke |
topic | Retrospective Clinical Research Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597044/ https://www.ncbi.nlm.nih.gov/pubmed/36271599 http://dx.doi.org/10.1177/03000605221132416 |
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