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Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis
BACKGROUND/AIMS: Depression and anxiety are associated with poorer outcomes in patients with hepatocellular carcinoma (HCC). However, the prevalence of depression and anxiety in HCC are unclear. We aimed to establish the prevalence of depression and anxiety in patients with HCC. METHODS: MEDLINE and...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Association for the Study of the Liver
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597225/ https://www.ncbi.nlm.nih.gov/pubmed/36263668 http://dx.doi.org/10.3350/cmh.2022.0136 |
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author | Tan, Darren Jun Hao Quek, Sabrina Xin Zi Yong, Jie Ning Suresh, Adithya Koh, Kaiser Xuan Ming Lim, Wen Hui Quek, Jingxuan Tang, Ansel Tan, Caitlyn Nah, Benjamin Tan, Eunice Keitoku, Taisei Muthiah, Mark D. Syn, Nicholas Ng, Cheng Han Kim, Beom Kyung Tamaki, Nobuharu Ho, Cyrus Su Hui Loomba, Rohit Huang, Daniel Q. |
author_facet | Tan, Darren Jun Hao Quek, Sabrina Xin Zi Yong, Jie Ning Suresh, Adithya Koh, Kaiser Xuan Ming Lim, Wen Hui Quek, Jingxuan Tang, Ansel Tan, Caitlyn Nah, Benjamin Tan, Eunice Keitoku, Taisei Muthiah, Mark D. Syn, Nicholas Ng, Cheng Han Kim, Beom Kyung Tamaki, Nobuharu Ho, Cyrus Su Hui Loomba, Rohit Huang, Daniel Q. |
author_sort | Tan, Darren Jun Hao |
collection | PubMed |
description | BACKGROUND/AIMS: Depression and anxiety are associated with poorer outcomes in patients with hepatocellular carcinoma (HCC). However, the prevalence of depression and anxiety in HCC are unclear. We aimed to establish the prevalence of depression and anxiety in patients with HCC. METHODS: MEDLINE and Embase were searched and original articles reporting prevalence of anxiety or depression in patients with HCC were included. A generalized linear mixed model with Clopper-Pearson intervals was used to obtain the pooled prevalence of depression and anxiety in patients with HCC. Risk factors were analyzed via a fractional-logistic regression model. RESULTS: Seventeen articles involving 64,247 patients with HCC were included. The pooled prevalence of depression and anxiety in patients with HCC was 24.04% (95% confidence interval [CI], 13.99–38.11%) and 22.20% (95% CI, 10.07–42.09%) respectively. Subgroup analysis determined that the prevalence of depression was lowest in studies where depression was diagnosed via clinician-administered scales (16.07%;95% CI, 4.42–44.20%) and highest in self-reported scales (30.03%; 95% CI, 17.19–47.01%). Depression in patients with HCC was lowest in the Americas (16.44%; 95% CI, 6.37–36.27%) and highest in South-East Asia (66.67%; 95% CI, 56.68–75.35%). Alcohol consumption, cirrhosis, and college education significantly increased risk of depression in patients with HCC. CONCLUSIONS: One in four patients with HCC have depression, while one in five have anxiety. Further studies are required to validate these findings, as seen from the wide CIs in certain subgroup analyses. Screening strategies for depression and anxiety should also be developed for patients with HCC. |
format | Online Article Text |
id | pubmed-9597225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Association for the Study of the Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-95972252022-10-31 Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis Tan, Darren Jun Hao Quek, Sabrina Xin Zi Yong, Jie Ning Suresh, Adithya Koh, Kaiser Xuan Ming Lim, Wen Hui Quek, Jingxuan Tang, Ansel Tan, Caitlyn Nah, Benjamin Tan, Eunice Keitoku, Taisei Muthiah, Mark D. Syn, Nicholas Ng, Cheng Han Kim, Beom Kyung Tamaki, Nobuharu Ho, Cyrus Su Hui Loomba, Rohit Huang, Daniel Q. Clin Mol Hepatol Original Article BACKGROUND/AIMS: Depression and anxiety are associated with poorer outcomes in patients with hepatocellular carcinoma (HCC). However, the prevalence of depression and anxiety in HCC are unclear. We aimed to establish the prevalence of depression and anxiety in patients with HCC. METHODS: MEDLINE and Embase were searched and original articles reporting prevalence of anxiety or depression in patients with HCC were included. A generalized linear mixed model with Clopper-Pearson intervals was used to obtain the pooled prevalence of depression and anxiety in patients with HCC. Risk factors were analyzed via a fractional-logistic regression model. RESULTS: Seventeen articles involving 64,247 patients with HCC were included. The pooled prevalence of depression and anxiety in patients with HCC was 24.04% (95% confidence interval [CI], 13.99–38.11%) and 22.20% (95% CI, 10.07–42.09%) respectively. Subgroup analysis determined that the prevalence of depression was lowest in studies where depression was diagnosed via clinician-administered scales (16.07%;95% CI, 4.42–44.20%) and highest in self-reported scales (30.03%; 95% CI, 17.19–47.01%). Depression in patients with HCC was lowest in the Americas (16.44%; 95% CI, 6.37–36.27%) and highest in South-East Asia (66.67%; 95% CI, 56.68–75.35%). Alcohol consumption, cirrhosis, and college education significantly increased risk of depression in patients with HCC. CONCLUSIONS: One in four patients with HCC have depression, while one in five have anxiety. Further studies are required to validate these findings, as seen from the wide CIs in certain subgroup analyses. Screening strategies for depression and anxiety should also be developed for patients with HCC. The Korean Association for the Study of the Liver 2022-10 2022-07-25 /pmc/articles/PMC9597225/ /pubmed/36263668 http://dx.doi.org/10.3350/cmh.2022.0136 Text en Copyright © 2022 by The Korean Association for the Study of the Liver https://creativecommons.org/licenses/by-nc/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Tan, Darren Jun Hao Quek, Sabrina Xin Zi Yong, Jie Ning Suresh, Adithya Koh, Kaiser Xuan Ming Lim, Wen Hui Quek, Jingxuan Tang, Ansel Tan, Caitlyn Nah, Benjamin Tan, Eunice Keitoku, Taisei Muthiah, Mark D. Syn, Nicholas Ng, Cheng Han Kim, Beom Kyung Tamaki, Nobuharu Ho, Cyrus Su Hui Loomba, Rohit Huang, Daniel Q. Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis |
title | Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis |
title_full | Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis |
title_fullStr | Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis |
title_full_unstemmed | Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis |
title_short | Global prevalence of depression and anxiety in patients with hepatocellular carcinoma: Systematic review and meta-analysis |
title_sort | global prevalence of depression and anxiety in patients with hepatocellular carcinoma: systematic review and meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597225/ https://www.ncbi.nlm.nih.gov/pubmed/36263668 http://dx.doi.org/10.3350/cmh.2022.0136 |
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