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Molecular determinants of TRAF6 binding specificity suggest that native interaction partners are not optimized for affinity

TRAF6 is an adaptor protein involved in signaling pathways that are essential for development and the immune system. It participates in many protein–protein interactions, some of which are mediated by the C‐terminal MATH domain, which binds to short peptide segments containing the motif PxExx[FYWHDE...

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Detalles Bibliográficos
Autores principales:	Halpin, Jackson C., Whitney, Dustin, Rigoldi, Federica, Sivaraman, Venkat, Singer, Avinoam, Keating, Amy E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2022
Materias:	Full‐length Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597381/ https://www.ncbi.nlm.nih.gov/pubmed/36305766 http://dx.doi.org/10.1002/pro.4429

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