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Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients

BACKGROUND: Serum 25‐hydroxyvitamin D [25(OH)D] level alters in colorectal cancer (CRC) development. Regulatory T (Treg) cells and T‐ helper type 17 (Th17) cells are involved in immune response. Th17‐mediated proinflammatory responses contribute to tumorigenesis, and Treg plays different roles in di...

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Autores principales: Chen, Bai, Jin, Liugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597490/
https://www.ncbi.nlm.nih.gov/pubmed/36301026
http://dx.doi.org/10.1002/iid3.723
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author Chen, Bai
Jin, Liugen
author_facet Chen, Bai
Jin, Liugen
author_sort Chen, Bai
collection PubMed
description BACKGROUND: Serum 25‐hydroxyvitamin D [25(OH)D] level alters in colorectal cancer (CRC) development. Regulatory T (Treg) cells and T‐ helper type 17 (Th17) cells are involved in immune response. Th17‐mediated proinflammatory responses contribute to tumorigenesis, and Treg plays different roles in different periods of CRC. Vitamin D deficiency is associated with significant variations in peripheral immune cells. This study investigated the relationship between Th17 and Treg cells and 25(OH)D level in CRC. METHODS: Ninety‐five CRC patients were included, as well as 80 healthy controls during the same period at the Affiliated Hospital of Jiangnan University. 25(OH)D level was analyzed through electrochemiluminescence (ECLIA). Th17 and Treg levels were evaluated through flow cytometry. Serum levels of interleukin (IL)‐10, IL‐17, IL‐23, and transforming growth factor‐β (TGF‐β), were analyzed through commercial enzyme‐linked immunoassay (ELISA) kits. RESULTS: 25(OH)D levels were downregulated in the serum of CRC patients. Decreased 25(OH)D level contributed to CRC pathogenesis. Decreased 25(OH)D level in CRC correlated with increased Treg and Th17 cell ratios and TGF‐β1, IL‐10, IL‐17, and IL‐23 levels in peripheral blood. CONCLUSION: Decreased 25(OH)D level in the serum of CRC patients had negative correlation with Treg and Th17 ratios and relative cytokines levels.
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spelling pubmed-95974902022-10-27 Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients Chen, Bai Jin, Liugen Immun Inflamm Dis Short Reports BACKGROUND: Serum 25‐hydroxyvitamin D [25(OH)D] level alters in colorectal cancer (CRC) development. Regulatory T (Treg) cells and T‐ helper type 17 (Th17) cells are involved in immune response. Th17‐mediated proinflammatory responses contribute to tumorigenesis, and Treg plays different roles in different periods of CRC. Vitamin D deficiency is associated with significant variations in peripheral immune cells. This study investigated the relationship between Th17 and Treg cells and 25(OH)D level in CRC. METHODS: Ninety‐five CRC patients were included, as well as 80 healthy controls during the same period at the Affiliated Hospital of Jiangnan University. 25(OH)D level was analyzed through electrochemiluminescence (ECLIA). Th17 and Treg levels were evaluated through flow cytometry. Serum levels of interleukin (IL)‐10, IL‐17, IL‐23, and transforming growth factor‐β (TGF‐β), were analyzed through commercial enzyme‐linked immunoassay (ELISA) kits. RESULTS: 25(OH)D levels were downregulated in the serum of CRC patients. Decreased 25(OH)D level contributed to CRC pathogenesis. Decreased 25(OH)D level in CRC correlated with increased Treg and Th17 cell ratios and TGF‐β1, IL‐10, IL‐17, and IL‐23 levels in peripheral blood. CONCLUSION: Decreased 25(OH)D level in the serum of CRC patients had negative correlation with Treg and Th17 ratios and relative cytokines levels. John Wiley and Sons Inc. 2022-10-26 /pmc/articles/PMC9597490/ /pubmed/36301026 http://dx.doi.org/10.1002/iid3.723 Text en © 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Reports
Chen, Bai
Jin, Liugen
Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients
title Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients
title_full Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients
title_fullStr Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients
title_full_unstemmed Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients
title_short Low serum level of 25‐OH vitamin D relates to Th17 and treg changes in colorectal cancer patients
title_sort low serum level of 25‐oh vitamin d relates to th17 and treg changes in colorectal cancer patients
topic Short Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9597490/
https://www.ncbi.nlm.nih.gov/pubmed/36301026
http://dx.doi.org/10.1002/iid3.723
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